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  A comprehensive approach for correcting voxel‐wise b‐value errors in diffusion MRI

Lee, Y., Kettinger, A. O., Wilm, B. J., Deichmann, R., Weiskopf, N., Lambert, C., et al. (2019). A comprehensive approach for correcting voxel‐wise b‐value errors in diffusion MRI. Magnetic Resonance in Medicine. doi:10.1002/mrm.28078.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0005-7046-E Version Permalink: http://hdl.handle.net/21.11116/0000-0005-BDDF-C
Genre: Journal Article

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 Creators:
Lee, Yoojin1, 2, Author
Kettinger, Adam O.3, 4, Author
Wilm, Bertram Jakob2, Author
Deichmann, Ralf5, 6, Author
Weiskopf, Nikolaus6, 7, Author              
Lambert, Christian6, Author
Pruessmann, Klaas Paul2, Author
Nagy, Zoltan1, 6, Author
Affiliations:
1Laboratory for Social and Neural Systems Research, Department of Economics, University of Zurich, Switzerland, ou_persistent22              
2Institute for Biomedical Engineering, University of Zurich, Switzerland, ou_persistent22              
3Brain Imaging Centre, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary, ou_persistent22              
4Department of Nuclear Techniques, Budapest University of Technology and Economics, Hungary, ou_persistent22              
5Brain Imaging Centre, Goethe University, Frankfurt, Germany, ou_persistent22              
6Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, United Kingdom, ou_persistent22              
7Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              

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Free keywords: b‐value; Diffusion gradient; Diffusion MRI; Diffusion tensor; Gradient nonlinearity
 Abstract: Purpose In diffusion MRI, the actual b‐value played out on the scanner may deviate from the nominal value due to magnetic field imperfections. A simple image‐based correction method for this problem is presented. Methods The apparent diffusion constant (ADC) of a water phantom was measured voxel‐wise along 64 diffusion directions at b = 1000 s/mm2. The true diffusion constant of water was estimated, considering the phantom temperature. A voxel‐wise correction factor, providing an effective b‐value including any magnetic field deviations, was determined for each diffusion direction by relating the measured ADC to the true diffusion constant. To test the method, the measured b‐value map was used to calculate the corrected voxel‐wise ADC for additionally acquired diffusion data sets on the same water phantom and data sets acquired on a small water phantom at three different positions. Diffusion tensor was estimated by applying the measured b‐value map to phantom and in vivo data sets. Results The b‐value‐corrected ADC maps of the phantom showed the expected spatial uniformity as well as a marked improvement in consistency across diffusion directions. The b‐value correction for the brain data resulted in a 5.8% and 5.5% decrease in mean diffusivity and angular differences of the primary diffusion direction of 2.71° and 0.73° inside gray and white matter, respectively. Conclusion The actual b‐value deviates significantly from its nominal setting, leading to a spatially variable error in the common diffusion outcome measures. The suggested method measures and corrects these artifacts.

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Language(s): eng - English
 Dates: 2019-09-232019-08-082019-10-222019-12-16
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1002/mrm.28078
Other: Epub ahead of print
PMID: 31840300
 Degree: -

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Project name : -
Grant ID : 2017‐1.2.1‐NKP‐2017‐00002
Funding program : Hungarian Brain Research Program (HBRP)
Funding organization : Semmelweis University Budapest, Hungary
Project name : -
Grant ID : 091593/Z/10/Z ; 079866/Z/06/Z
Funding program : -
Funding organization : Wellcome Trust
Project name : -
Grant ID : 31003A_166118 ; 316030_164076
Funding program : -
Funding organization : Swiss National Science Foundation

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Title: Magnetic Resonance in Medicine
Source Genre: Journal
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Publ. Info: New York : Wiley-Liss
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 0740-3194
CoNE: https://pure.mpg.de/cone/journals/resource/954925538149