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  A neural circuit arbitrates between persistence and withdrawal in hungry Drosophila

Sayin, S., De Backer, J.-F., Siju, K. P., Wosniack, M. E., Lewis, L. P., Frisch, L.-M., et al. (2019). A neural circuit arbitrates between persistence and withdrawal in hungry Drosophila. Neuron, 104(3), 544-558.e6. doi:10.1016/j.neuron.2019.07.028.

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 Creators:
Sayin, Sercan, Author
De Backer, Jean-Francois, Author
Siju, K. P., Author
Wosniack, Marina E., Author
Lewis, Laurence P.1, Author           
Frisch, Lisa-Marie, Author
Gansen, Benedikt, Author
Schlegel, Philipp, Author
Edmondson-Stait, Amelia, Author
Sharifi, Nadiya, Author
Fisher, Corey B., Author
Calle-Schuler, Steven A., Author
Lauritzen, J. Scott, Author
Bock, Davi D., Author
Costa, Marta, Author
Jefferis, Gregory S. X. E., Author
Gjorgjieva, Julijana, Author
Grunwald Kadow, Ilona C.1, Author           
Affiliations:
1Max Planck Research Group: Chemosensory coding / Grunwald-Kadow, MPI of Neurobiology, Max Planck Society, ou_1113556              

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Free keywords: BODY EFFERENT NEURONS; MUSHROOM BODY; DOPAMINERGIC-NEURONS; OLFACTORY BEHAVIOR; MEMORY RETRIEVAL; BITTER TASTE; 2 PAIRS; OCTOPAMINE; REWARD; FOODNeurosciences & Neurology;
 Abstract: In pursuit of food, hungry animals mobilize significant energy resources and overcome exhaustion and fear. How need and motivation control the decision to continue or change behavior is not understood. Using a single fly treadmill, we show that hungry flies persistently track a food odor and increase their effort over repeated trials in the absence of reward suggesting that need dominates negative experience. We further show that odor tracking is regulated by two mushroom body output neurons (MBONs) connecting the MB to the lateral horn. These MBONs, together with dopaminergic neurons and Dop1R2 signaling, control behavioral persistence. Conversely, an octopaminergic neuron, VPM4, which directly innervates one of the MBONs, acts as a brake on odor tracking by connecting feeding and olfaction. Together, our data suggest a function for the MB in internal state-dependent expression of behavior that can be suppressed by external inputs conveying a competing behavioral drive.

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Language(s): eng - English
 Dates: 2019-11-06
 Publication Status: Issued
 Pages: 21
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Degree: -

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Title: Neuron
Source Genre: Journal
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Publ. Info: Cambridge, Mass. : Cell Press
Pages: - Volume / Issue: 104 (3) Sequence Number: - Start / End Page: 544 - 558.e6 Identifier: ISSN: 0896-6273
CoNE: https://pure.mpg.de/cone/journals/resource/954925560565