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  Cilia-driven flows in the brain third ventricle.

Eichele, G., Bodenschatz, E., Ditte, Z., Günther, A. K., Kapoor, S., Wang, Y., et al. (2019). Cilia-driven flows in the brain third ventricle. Philosophical Transactions of the Royal Society of London, Series B: Biological Sciences, 375(1792): 20190154. doi:10.1098/rstb.2019.0154.

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Eichele, G.1, Autor           
Bodenschatz, E., Autor
Ditte, Z.1, Autor           
Günther, A. K.1, Autor           
Kapoor, S.1, Autor           
Wang, Y., Autor
Westendorf, C., Autor
Affiliations:
1Department of Genes and Behavior, MPI for Biophysical Chemistry, Max Planck Society, ou_persistent34              

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Schlagwörter: cerebrospinal fluid; extracellular vesicles; fluid dynamics; translational polarity; hypothalamus; tanycyte
 Zusammenfassung: The brain ventricles are interconnected, elaborate cavities that traverse the brain. They are filled with cerebrospinal fluid (CSF) that is, to a large part, produced by the choroid plexus, a secretory epithelium that reaches into the ventricles. CSF is rich in cytokines, growth factors and extracellular vesicles that glide along the walls of ventricles, powered by bundles of motile cilia that coat the ventricular wall. We review the cellular and biochemical properties of the ventral part of the third ventricle that is surrounded by the hypothalamus. In particular, we consider the recently discovered intricate network of cilia-driven flows that characterize this ventricle and discuss the potential physiological significance of this flow for the directional transport of CSF signals to cellular targets located either within the third ventricle or in the adjacent hypothalamic brain parenchyma. Cilia-driven streams of signalling molecules offer an exciting perspective on how fluid-borne signals are dynamically transmitted in the brain. This article is part of the Theo Murphy meeting issue 'Unity and diversity of cilia in locomotion and transport'.

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Sprache(n): eng - English
 Datum: 2019-12-30
 Publikationsstatus: Online veröffentlicht
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 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1098/rstb.2019.0154
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Titel: Philosophical Transactions of the Royal Society of London, Series B : Biological Sciences
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: -
Seiten: 7 Band / Heft: 375 (1792) Artikelnummer: 20190154 Start- / Endseite: - Identifikator: -