English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Cilia-driven flows in the brain third ventricle.

Eichele, G., Bodenschatz, E., Ditte, Z., Günther, A. K., Kapoor, S., Wang, Y., et al. (2019). Cilia-driven flows in the brain third ventricle. Philosophical Transactions of the Royal Society of London, Series B: Biological Sciences, 375(1792): 20190154. doi:10.1098/rstb.2019.0154.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0005-7551-C Version Permalink: http://hdl.handle.net/21.11116/0000-0005-7554-9
Genre: Journal Article

Files

show Files
hide Files
:
3186062.pdf (Publisher version), 2MB
 
File Permalink:
-
Name:
3186062.pdf
Description:
-
Visibility:
Restricted ( Max Planck Society (every institute); )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Eichele, G.1, Author              
Bodenschatz, E., Author
Ditte, Z.1, Author              
Günther, A. K.1, Author              
Kapoor, S.1, Author              
Wang, Y., Author
Westendorf, C., Author
Affiliations:
1Department of Genes and Behavior, MPI for Biophysical Chemistry, Max Planck Society, ou_persistent34              

Content

show
hide
Free keywords: cerebrospinal fluid; extracellular vesicles; fluid dynamics; translational polarity; hypothalamus; tanycyte
 Abstract: The brain ventricles are interconnected, elaborate cavities that traverse the brain. They are filled with cerebrospinal fluid (CSF) that is, to a large part, produced by the choroid plexus, a secretory epithelium that reaches into the ventricles. CSF is rich in cytokines, growth factors and extracellular vesicles that glide along the walls of ventricles, powered by bundles of motile cilia that coat the ventricular wall. We review the cellular and biochemical properties of the ventral part of the third ventricle that is surrounded by the hypothalamus. In particular, we consider the recently discovered intricate network of cilia-driven flows that characterize this ventricle and discuss the potential physiological significance of this flow for the directional transport of CSF signals to cellular targets located either within the third ventricle or in the adjacent hypothalamic brain parenchyma. Cilia-driven streams of signalling molecules offer an exciting perspective on how fluid-borne signals are dynamically transmitted in the brain. This article is part of the Theo Murphy meeting issue 'Unity and diversity of cilia in locomotion and transport'.

Details

show
hide
Language(s): eng - English
 Dates: 2019-12-30
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1098/rstb.2019.0154
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Philosophical Transactions of the Royal Society of London, Series B : Biological Sciences
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: 7 Volume / Issue: 375 (1792) Sequence Number: 20190154 Start / End Page: - Identifier: -