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  Mechanisms for active regulation of biomolecular condensates

Söding, J., Zwicker, D., Sohrabi-Jahromi, S., Böhning, M., & Kirschbaum, J. (2020). Mechanisms for active regulation of biomolecular condensates. Trends in Cell Biology, 30(1), 4-14. doi:10.1016/j.tcb.2019.10.006.

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Söding, J., Autor
Zwicker, David1, Autor           
Sohrabi-Jahromi, S., Autor
Böhning, M., Autor
Kirschbaum, Jan1, Autor           
Affiliations:
1Max Planck Research Group Theory of Biological Fluids, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society, ou_2516693              

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Schlagwörter: Cajal bodies; DNA repair; membraneless organelles; size control; stress granules; synapsin
 Zusammenfassung: Liquid-liquid phase separation is a key organizational principle in eukaryotic cells, on par with intracellular membranes. It allows cells to concentrate specific proteins into condensates, increasing reaction rates and achieving switch-like regulation. We propose two active mechanisms that can explain how cells regulate condensate formation and size. In both, the cell regulates the activity of an enzyme, often a kinase, that adds post-translational modifications to condensate proteins. In enrichment inhibition, the enzyme enriches in the condensate and weakens interactions, as seen in stress granules (SGs), Cajal bodies, and P granules. In localization-induction, condensates form around immobilized enzymes that strengthen interactions, as observed in DNA repair, transmembrane signaling, and microtubule assembly. These models can guide studies into the many emerging roles of biomolecular condensates.

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Sprache(n): eng - English
 Datum: 2019-11-182020-01-01
 Publikationsstatus: Erschienen
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 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1016/j.tcb.2019.10.006
 Art des Abschluß: -

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Titel: Trends in Cell Biology
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 30 (1) Artikelnummer: - Start- / Endseite: 4 - 14 Identifikator: -