English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Skin conductance responses and neural activations during fear conditioning and extinction recall across anxiety disorders

Marin, M.-F., Zsido, R., Song, H., Lasko, N. B., Killgore, W. D. S., Rauch, S. L., et al. (2017). Skin conductance responses and neural activations during fear conditioning and extinction recall across anxiety disorders. JAMA Psychiatry, 74(6), 622-631. doi:10.1001/jamapsychiatry.2017.0329.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0005-7709-C Version Permalink: http://hdl.handle.net/21.11116/0000-0007-0048-8
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Marin, Marie-France, Author
Zsido, Rachel1, Author              
Song, Huijin, Author
Lasko, Natasha B., Author
Killgore, William D. S., Author
Rauch, Scott L., Author
Simon, Naomi M., Author
Milad, Mohammed R., Author
Affiliations:
1External Organizations, ou_persistent22              

Content

show
hide
Free keywords: -
 Abstract: Importance The fear conditioning and extinction neurocircuitry has been extensively studied in healthy and clinical populations, with a particular focus on posttraumatic stress disorder. Despite significant overlap of symptoms between posttraumatic stress disorder and anxiety disorders, the latter has received less attention. Given that dysregulated fear levels characterize anxiety disorders, examining the neural correlates of fear and extinction learning may shed light on the pathogenesis of underlying anxiety disorders. Objectives To investigate the psychophysiological and neural correlates of fear conditioning and extinction recall in anxiety disorders and to document how these features differ as a function of multiple diagnoses or anxiety severity. Design, Setting, and Participants This investigation was a cross-sectional, case-control, functional magnetic resonance imaging study at an academic medical center. Participants were healthy controls and individuals with at least 1 of the following anxiety disorders: generalized anxiety disorder, social anxiety disorder, specific phobia, and panic disorder. The study dates were between March 2013 and May 2015. Exposures Two-day fear conditioning and extinction paradigm. Main Outcomes and Measures Skin conductance responses, blood oxygenation level–dependent responses, trait anxiety scores from the State Trait Anxiety Inventory–Trait Form, and functional connectivity. Results This study included 21 healthy controls (10 women) and 61 individuals with anxiety disorders (36 women). P values reported for the neuroimaging results are all familywise error corrected. Skin conductance responses during extinction recall did not differ between individuals with anxiety disorders and healthy controls (ηp2 = 0.001, P = .79), where ηp2 is partial eta squared. The anxiety group had lower activation of the ventromedial prefrontal cortex (vmPFC) during extinction recall (ηp2 = 0.178, P = .02). A similar hypoactive pattern was found during early conditioning (ηp2 = 0.106, P = .009). The vmPFC hypoactivation was associated with anxiety symptom severity (r = −0.420, P = .01 for conditioning and r = −0.464, P = .004 for extinction recall) and the number of co-occuring anxiety disorders diagnosed (ηp2 = 0.137, P = .009 for conditioning and ηp2 = 0.227, P = .004 for extinction recall). Psychophysiological interaction analyses revealed that the fear network connectivity differed between healthy controls and the anxiety group during fear learning (ηp2 range between 0.088 and 0.176 and P range between 0.02 and 0.003) and extinction recall (ηp2 range between 0.111 and 0.235 and P range between 0.02 and 0.002). Conclusions and Relevance Despite no skin conductance response group differences during extinction recall, brain activation patterns between anxious and healthy individuals differed. These findings encourage future studies to examine the conditions longitudinally and in the context of treatment trials to improve and guide therapeutics via advanced neurobiological understanding of each disorder.

Details

show
hide
Language(s): eng - English
 Dates: 2017-06
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1001/jamapsychiatry.2017.0329
PMID: 28403387
PMC: PMC5539837
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: JAMA Psychiatry
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Chicago, Ill. : American Medical Association
Pages: - Volume / Issue: 74 (6) Sequence Number: - Start / End Page: 622 - 631 Identifier: Other: 2168-6238
CoNE: https://pure.mpg.de/cone/journals/resource/2168-6238