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  Effect of DNA polymerase I and DNA helicase II on the turnover rate of UvrABC excision nuclease

Husain, I., Houten, B. V., Thomas, D. C., Abdel-Monem, M., & Sancar, A. (1985). Effect of DNA polymerase I and DNA helicase II on the turnover rate of UvrABC excision nuclease. Proceedings of the National Academy of Sciences of the United States of America, 82(20), 6774-6778. doi:10.1073/pnas.82.20.6774.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0005-7771-6 Version Permalink: https://hdl.handle.net/21.11116/0000-0005-7772-5
Genre: Journal Article

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PNAS_82_1985_6774.pdf (Any fulltext), 2MB
 
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https://www.pnas.org/content/pnas/82/20/6774.full.pdf (Any fulltext)
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 Creators:
Husain, Intisar, Author
Houten, Bennett Van, Author
Thomas, David C., Author
Abdel-Monem, Mahmoud1, Author           
Sancar, Aziz, Author
Affiliations:
1Max Planck Institute for Medical Research, Max Planck Society, ou_1125545              

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 Abstract: UvrABC excision nuclease (UvrA, UvrB, and UvrC proteins) of Escherichia coli removes nucleotide mono- and diadducts from DNA in the form of oligonucleotides 12 or 13 bases long. We find that the purified enzyme dissociates from DNA very slowly, if at all, in the absence of other proteins implicated in excision repair. Addition of DNA polymerase I and helicase II (UvrD protein) to the reaction mixture stimulates the turnover rate of the excision nuclease to a level comparable to that observed in vivo.

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Language(s): eng - English
 Dates: 1985-06-201985-10-01
 Publication Status: Issued
 Pages: 5
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1073/pnas.82.20.6774
URI: https://www.ncbi.nlm.nih.gov/pubmed/2931721
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Title: Proceedings of the National Academy of Sciences of the United States of America
  Other : Proc. Acad. Sci. USA
  Other : Proc. Acad. Sci. U.S.A.
  Other : Proceedings of the National Academy of Sciences of the USA
  Abbreviation : PNAS
Source Genre: Journal
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Publ. Info: Washington, D.C. : National Academy of Sciences
Pages: - Volume / Issue: 82 (20) Sequence Number: - Start / End Page: 6774 - 6778 Identifier: ISSN: 0027-8424
CoNE: https://pure.mpg.de/cone/journals/resource/954925427230