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  Mutual Zonated Interactions of Wnt and Hh Signaling Are Orchestrating the Metabolism of the Adult Liver in Mice and Human

Kolbe, E., Aleithe, S., Rennert, C., Spormann, L., Ott, F., Meierhofer, D., et al. (2019). Mutual Zonated Interactions of Wnt and Hh Signaling Are Orchestrating the Metabolism of the Adult Liver in Mice and Human. Cell Reports, 29(13): e7, pp. 4553-4567. doi:10.1016/j.celrep.2019.11.104.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0005-796B-C Version Permalink: http://hdl.handle.net/21.11116/0000-0005-796C-B
Genre: Journal Article

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Kolbe, Erik , Author
Aleithe, Susanne , Author
Rennert, Christiane , Author
Spormann, Luise , Author
Ott, Fritzi, Author
Meierhofer, David1, Author              
Gajowski, Robert1, Author              
Stöpel, Claus , Author
Hoehme, Stefan , Author
Kücken, Michael , Author
Brusch, Lutz, Author
Seifert, Michael , Author
von Schoenfels, Witigo , Author
Schafmayer, Clemens , Author
Brosch, Mario , Author
Hoffmann, Ute, Author
Damm, Georg, Author
Seehofer, Daniel , Author
Hampe, Jochen , Author
Gebhardt, Rolf , Author
Matz-Soja, Madlen , Author more..
Affiliations:
1Mass Spectrometry (Head: David Meierhofer), Scientific Service (Head: Christoph Krukenkamp), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479669              

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 Abstract: The Hedgehog (Hh) and Wnt/β-Catenin (Wnt) cascades are morphogen pathways whose pronounced influence on adult liver metabolism has been identified in recent years. How both pathways communicate and control liver metabolic functions are largely unknown. Detecting core components of Wnt and Hh signaling and mathematical modeling showed that both pathways in healthy liver act largely complementary to each other in the pericentral (Wnt) and the periportal zone (Hh) and communicate mainly by mutual repression. The Wnt/Hh module inversely controls the spatiotemporal operation of various liver metabolic pathways, as revealed by transcriptome, proteome, and metabolome analyses. Shifting the balance to Wnt (activation) or Hh (inhibition) causes pericentralization and periportalization of liver functions, respectively. Thus, homeostasis of the Wnt/Hh module is essential for maintaining proper liver metabolism and to avoid the development of certain metabolic diseases. With caution due to minor species-specific differences, these conclusions may hold for human liver as well.

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Language(s): eng - English
 Dates: 2019-11-252019-12-24
 Publication Status: Published online
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 Rev. Method: -
 Identifiers: DOI: 10.1016/j.celrep.2019.11.104
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Title: Cell Reports
Source Genre: Journal
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Publ. Info: Maryland Heights, MO : Cell Press
Pages: 15 Volume / Issue: 29 (13) Sequence Number: e7 Start / End Page: 4553 - 4567 Identifier: ISSN: 2211-1247
CoNE: https://pure.mpg.de/cone/journals/resource/2211-1247