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  Dietary Intake Regulates the Circulating Inflammatory Monocyte Pool

Jordan, S., Tung, N., Casanova-Acebes, M., Chang, C., Cantoni, C., Zhang, D., et al. (2019). Dietary Intake Regulates the Circulating Inflammatory Monocyte Pool. CELL, 178(5), 1102-1114.e17. doi:10.1016/j.cell.2019.07.050.

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Genre: Journal Article

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 Creators:
Jordan, Stefan1, Author
Tung, Navpreet1, Author
Casanova-Acebes, Maria1, Author
Chang, Christie1, Author
Cantoni, Claudia1, Author
Zhang, Dachuan1, Author
Wirtz, Theresa H.1, Author
Naik, Shruti1, Author
Rose, Samuel A.1, Author
Brocker, Chad N.1, Author
Gainullina, Anastasiia1, Author
Hornburg, Daniel2, Author              
Horng, Sam1, Author
Maier, Barbara B.1, Author
Cravedi, Paolo1, Author
LeRoith, Derek1, Author
Gonzalez, Frank J.1, Author
Meissner, Felix3, Author              
Ochando, Jordi1, Author
Rahman, Adeeb1, Author
Chipuk, Jerry E.1, AuthorArtyomov, Maxim N.1, AuthorFrenette, Paul S.1, AuthorPiccio, Laura1, AuthorBerres, Marie-Luise1, AuthorGallagher, Emily J.1, AuthorMerad, Miriam1, Author more..
Affiliations:
1external, ou_persistent22              
2Mann, Matthias / Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565159              
3Meissner, Felix / Experimental Systems Immunology, Max Planck Institute of Biochemistry, Max Planck Society, ou_2149678              

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Free keywords: WEIGHT-LOSS; BONE-MARROW; VEGETARIAN DIET; LOW-CALORIE; OVERWEIGHT; AUTOIMMUNITY; PROTEIN; STEM; PARAMETERS; EMIGRATIONBiochemistry & Molecular Biology; Cell Biology;
 Abstract: Caloric restriction is known to improve inflammatory and autoimmune diseases. However, the mechanisms by which reduced caloric intake modulates inflammation are poorly understood. Here we show that short-term fasting reduced monocyte metabolic and inflammatory activity and drastically reduced the number of circulating monocytes. Regulation of peripheral monocyte numbers was dependent on dietary glucose and protein levels. Specifically, we found that activation of the low-energy sensor 5'-AMP-activated protein kinase (AMPK) in hepato-cytes and suppression of systemic CCL2 production by peroxisome proliferator-activator receptor alpha (PPAR alpha) reduced monocyte mobilization from the bone marrow. Importantly, we show that fasting improves chronic inflammatory diseases without compromising monocyte emergency mobilization during acute infectious inflammation and tissue repair. These results reveal that caloric intake and liver energy sensors dictate the blood and tissue immune tone and link dietary habits to inflammatory disease outcome.

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Language(s): eng - English
 Dates: 2019-08-22
 Publication Status: Published in print
 Pages: 30
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Degree: -

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Title: CELL
Source Genre: Journal
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Publ. Info: 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA : CELL PRESS
Pages: - Volume / Issue: 178 (5) Sequence Number: - Start / End Page: 1102 - 1114.e17 Identifier: ISSN: 0092-8674