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  Molecular analysis of virulence determinants of neisseria gonorrhoeae

Meyer, T. F., Haas, R., Halter, R., Nickel, P., Pohlner, J., Stern, A., et al. (1985). Molecular analysis of virulence determinants of neisseria gonorrhoeae. The Pathogenesis of Bacterial Infections, 221-234. doi:10.1007/978-3-642-70351-5_19.

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Pathogenesis BacterialInfections_1985_221.pdf (Any fulltext), 2MB
 
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Meyer, Thomas F.1, Author           
Haas , R., Author
Halter, R., Author
Nickel, P., Author
Pohlner, J., Author
Stern, A., Author
Clarke, J., Author
Delius, H., Author
So, M., Author
Affiliations:
1Max Planck Institute for Medical Research, Max Planck Society, ou_1125545              

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Free keywords: Outer Membrane Protein, Neisseria Gonorrhoeae, Antigenic Variation, Gonococcus Infection, Extracellular Secretion
 Abstract: Gonococcal virulence is thought to rely on multiple phenomena to which antigenic variation of surface proteins as well as the production of an extracellular protease specific for human IgA1 can be accounted. The expression of pilin and opacity (Op) protein in Neisseria gonorrhoeae can be switched on and off and a single cell apparently has a whole repertoire of genes to express many serologically distinguishable protein types. In order to investigate the molecular mechanisms associated with this surface variability, we have cloned the genes for pilin and Op expression in Escherichia coli. Using these genes as probes in DNA filter hybridizations, we revealed two complex gene systems which undergo genomic reorganizations and/or gene conversions which occur concomitant to changes in the expression of these surface proteins. To study the role of IgA proteases in bacterial pathogenesis, we cloned the IgA protease gene of N. gonorrhoeae MS11. This clone promotes expression and extracellular secretion of active enzyme in E. coli and other gram-negative bacterial species.

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Language(s): eng - English
 Dates: 1985
 Publication Status: Issued
 Pages: 14
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1007/978-3-642-70351-5_19
 Degree: -

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Title: The Pathogenesis of Bacterial Infections
Source Genre: Journal
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Publ. Info: Berlin Heidelberg : Springer-Verlag
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 221 - 234 Identifier: ISBN: 978-3-642-70353-9
ISBN: 978-3-642-70351-5