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  Converging patterns of ageing-associated brain volume loss and tissue microstructure differences

Taubert, M., Roggenhofer, E., Melie-Garcia, L., Muller, S., Lehmann, N., Preisig, M., et al. (2020). Converging patterns of ageing-associated brain volume loss and tissue microstructure differences. Neurobiology of Aging. doi:10.1016/j.neurobiolaging.2020.01.006.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0005-7E21-9 Version Permalink: http://hdl.handle.net/21.11116/0000-0005-7E22-8
Genre: Journal Article

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 Creators:
Taubert, Marco1, 2, 3, Author              
Roggenhofer, Elisabeth4, Author
Melie-Garcia, Lester4, Author
Muller, Sandrine4, Author
Lehmann, Nico1, Author
Preisig, Martin5, Author
Vollenweider, Peter6, Author
Marques-Vidal, Pedro6, Author
Lutti, Antoine4, Author
Kherif, Ferath4, Author
Draganski, Bogdan3, 4, Author              
Affiliations:
1Faculty of Humanities, Social Science & Education, Otto von Guericke University Magdeburg, Germany, ou_persistent22              
2Center for Behavioral Brain Sciences, Magdeburg, Germany, ou_persistent22              
3Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
4Département des Neurosciences Cliniques, Laboratoire de Recherche en Neuroimagerie (LREN), Centre hospitalier universitaire vaudois, Lausanne, Switzerland, ou_persistent22              
5Department of Psychiatry, Centre hospitalier universitaire vaudois, Lausanne, Switzerland, ou_persistent22              
6Department of Medicine, Centre hospitalier universitaire vaudois, Lausanne, Switzerland, ou_persistent22              

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 Abstract: Given the worldwide increasing socio-economic burden of ageing-associated brain diseases, there is pressing need to gain in-depth knowledge about the neuro-biology of brain anatomy changes across the lifespan. Advances in quantitative magnetic resonance imaging (MRI) sensitive to brain’s myelin, iron and free water content allow for a detailed in vivo investigation of ageing-related changes whilst reducing spurious morphometry differences. Main aim of our study is to link previous morphometry findings in ageing to microstructural tissue properties in a large-scale cohort (n=966, age range 46-86y). Addressing previous controversies in the field, we present results obtained with different approaches to adjust local findings for global effects. Beyond the confirmation of age-related atrophy, myelin and free water decreases, we report proportionally steeper volume, iron and myelin decline in sensorimotor and subcortical areas paralleled by free water increase. We demonstrate ageing-related white matter volume, myelin and iron loss in fronto-striatal projections. Our findings provide robust evidence for spatial overlap between volume and tissue property differences in ageing that affect predominantly motor and executive networks.

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Language(s): eng - English
 Dates: 2020-01-082019-07-212020-01-132020-01-15
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
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Title: Neurobiology of Aging
  Other : Neurobiol. Aging
Source Genre: Journal
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Publ. Info: New York, NY [etc.] : Elsevier
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 0197-4580
CoNE: https://pure.mpg.de/cone/journals/resource/954925491902