English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Linking aberrant chromatin features in chronic lymphocytic leukemia to transcription factor networks

Mallm, J. P., Iskar, M., Ishaque, N., Klett, L. C., Kugler, S. J., Muino, J. M., et al. (2019). Linking aberrant chromatin features in chronic lymphocytic leukemia to transcription factor networks. Molecular Systems Biology, 15(5): e8339. doi:10.15252/msb.20188339.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0005-9081-5 Version Permalink: http://hdl.handle.net/21.11116/0000-0005-9082-4
Genre: Journal Article

Files

show Files
hide Files
:
Mallm_2019.pdf (Publisher version), 4MB
Name:
Mallm_2019.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
© 2019 The Authors

Locators

show
hide
Description:
-

Creators

show
hide
 Creators:
Mallm, J. P., Author
Iskar, M., Author
Ishaque, N., Author
Klett, L. C., Author
Kugler, S. J., Author
Muino, Jose M.1, Author              
Teif, V. B., Author
Poos, A. M., Author
Grossmann, S., Author
Erdel, F., Author
Tavernari, D., Author
Koser, S. D., Author
Schumacher, S., Author
Brors, B., Author
Konig, R., Author
Remondini, D., Author
Vingron, Martin2, Author              
Stilgenbauer, S., Author
Lichter, P., Author
Zapatka, M., Author
Mertens, D., AuthorRippe, K., Author more..
Affiliations:
1Dept. of Computational Molecular Biology (Head: Martin Vingron), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433547              
2Gene regulation (Martin Vingron), Dept. of Computational Molecular Biology (Head: Martin Vingron), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479639              

Content

show
hide
Free keywords: DNA methylation bivalent promoter enhancer gene regulatory networks histone modifications
 Abstract: In chronic lymphocytic leukemia (CLL), a diverse set of genetic mutations is embedded in a deregulated epigenetic landscape that drives cancerogenesis. To elucidate the role of aberrant chromatin features, we mapped DNA methylation, seven histone modifications, nucleosome positions, chromatin accessibility, binding of EBF1 and CTCF, as well as the transcriptome of B cells from CLL patients and healthy donors. A globally increased histone deacetylase activity was detected and half of the genome comprised transcriptionally downregulated partially DNA methylated domains demarcated by CTCF CLL samples displayed a H3K4me3 redistribution and nucleosome gain at promoters as well as changes of enhancer activity and enhancer linkage to target genes. A DNA binding motif analysis identified transcription factors that gained or lost binding in CLL at sites with aberrant chromatin features. These findings were integrated into a gene regulatory enhancer containing network enriched for B-cell receptor signaling pathway components. Our study predicts novel molecular links to targets of CLL therapies and provides a valuable resource for further studies on the epigenetic contribution to the disease.

Details

show
hide
Language(s): eng - English
 Dates: 2019-04-172019-05-22
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.15252/msb.20188339
ISSN: 1744-4292 (Electronic)1744-4292 (Print)
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Molecular Systems Biology
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: London : Nature Pub. Group
Pages: - Volume / Issue: 15 (5) Sequence Number: e8339 Start / End Page: - Identifier: CoNE: https://pure.mpg.de/cone/journals/resource/1000000000021290