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  The Translational Landscape of the Human Heart

van Heesch, S., Witte, F., Schneider-Lunitz, V., Schulz, J. F., Adami, E., Faber, A. B., et al. (2019). The Translational Landscape of the Human Heart. Cell, 178(1): e29, pp. 242-260. doi:10.1016/j.cell.2019.05.010.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0005-907A-F Version Permalink: http://hdl.handle.net/21.11116/0000-0005-907B-E
Genre: Journal Article

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 Creators:
van Heesch, S., Author
Witte, F., Author
Schneider-Lunitz, V., Author
Schulz, J. F., Author
Adami, E., Author
Faber, A. B., Author
Kirchner, M., Author
Maatz, H., Author
Blachut, S., Author
Sandmann, C. L., Author
Kanda, M., Author
Worth, C. L., Author
Schafer, S., Author
Calviello, L., Author
Merriott, R., Author
Patone, G., Author
Hummel, O., Author
Wyler, E., Author
Obermayer, B., Author
Mucke, M. B., Author
Lindberg, E. L., AuthorTrnka, F., AuthorMemczak, S., AuthorSchilling, M., AuthorFelkin, L. E., AuthorBarton, P. J. R., AuthorQuaife, N. M., AuthorVanezis, K., AuthorDiecke, S., AuthorMukai, M., AuthorMah, N., AuthorOh, S. J., AuthorKurtz, A., AuthorSchramm, C., AuthorSchwinge, D., AuthorSebode, M., AuthorHarakalova, M., AuthorAsselbergs, F. W., AuthorVink, A., Authorde Weger, R. A., AuthorViswanathan, S., AuthorWidjaja, A. A., AuthorGartner-Rommel, A., AuthorMilting, H., AuthorDos Remedios, C., AuthorKnosalla, C., AuthorMertins, P., AuthorLandthaler, M., AuthorVingron, Martin1, Author              Linke, W. A., AuthorSeidman, J. G., AuthorSeidman, C. E., AuthorRajewsky, N., AuthorOhler, U., AuthorCook, S. A., AuthorHubner, N., Author more..
Affiliations:
1Gene regulation (Martin Vingron), Dept. of Computational Molecular Biology (Head: Martin Vingron), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479639              

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Free keywords: ORF detection circRNAs dilated cardiomyopathy heart failure human heart lncRNAs microproteins protein-truncating variants ribosome profiling short ORFs titin translational regulation translatome
 Abstract: Gene expression in human tissue has primarily been studied on the transcriptional level, largely neglecting translational regulation. Here, we analyze the translatomes of 80 human hearts to identify new translation events and quantify the effect of translational regulation. We show extensive translational control of cardiac gene expression, which is orchestrated in a process-specific manner. Translation downstream of predicted disease-causing protein-truncating variants appears to be frequent, suggesting inefficient translation termination. We identify hundreds of previously undetected microproteins, expressed from lncRNAs and circRNAs, for which we validate the protein products in vivo. The translation of microproteins is not restricted to the heart and prominent in the translatomes of human kidney and liver. We associate these microproteins with diverse cellular processes and compartments and find that many locate to the mitochondria. Importantly, dozens of microproteins are translated from lncRNAs with well-characterized noncoding functions, indicating previously unrecognized biology.

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Language(s): eng - English
 Dates: 2019-05-302019-06-27
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.cell.2019.05.010
ISSN: 1097-4172 (Electronic)0092-8674 (Print)
 Degree: -

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Title: Cell
Source Genre: Journal
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Publ. Info: Cambridge, Mass. : Cell Press
Pages: - Volume / Issue: 178 (1) Sequence Number: e29 Start / End Page: 242 - 260 Identifier: CoNE: https://pure.mpg.de/cone/journals/resource/954925463183