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  Homeostatic, reward and executive brain functions after gastric bypass surgery

Hankir, M. K., Al-Bas, S., Rullmann, M., Chakaroun, R., Seyfried, F., & Pleger, B. (2020). Homeostatic, reward and executive brain functions after gastric bypass surgery. Appetite, 146: 104419. doi:10.1016/j.appet.2019.104419.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0005-80E3-9 Version Permalink: http://hdl.handle.net/21.11116/0000-0005-80E4-8
Genre: Journal Article

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 Creators:
Hankir, Mohammed K.1, Author
Al-Bas, Siham2, Author
Rullmann, Michael3, 4, Author              
Chakaroun, Rima4, Author
Seyfried, Florian5, Author
Pleger, Burkhard2, 3, 4, Author              
Affiliations:
1Department of Surgery, University Hospital Würzburg, Germany, ou_persistent22              
2Department of Neurology, University Hospital Bergmannsheil, Bochum, Germany, ou_persistent22              
3Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
4Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany, ou_persistent22              
5Department of General, Visceral, Vascular and Pediatric Surgery, University Hospital Würzburg, Germany, ou_persistent22              

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Free keywords: Brain imaging; Food reward; Gut-brain communication; Obesity; Roux-en-Y gastric bypass
 Abstract: Obesity in part arises from the regular overconsumption of palatable, caloric-dense foods. This maladaptive eating behavior has been described as impulsive, compulsive and even addictive, and has its origins in molecular and cellular aberrations in the gut and brain. Mounting evidence from human and rodent studies suggests that Roux-en-Y gastric bypass (RYGB) surgery persistantly promotes lower caloric intake by modifying gut-brain communication. In this Review, we discuss how the changes in gut hormones, nutrient sensing andmicrobiota brought about by RYGB together favourably regulate homeostatic, reward and executive brain functions. We further speculate on how this lastingly establishes a negative whole-body energy balance in the face of plenty. Future studies will more completely characterize the role of modified gut-brain communication in the healthier eating behavior following RYGB, possibly facilitating the development of more effective, non-surgical weight loss treatments.

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Language(s): eng - English
 Dates: 2019-07-012019-02-042019-08-232019-08-282020-03-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.appet.2019.104419
Other: Epub 2019
PMID: 31472199
 Degree: -

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Title: Appetite
Source Genre: Journal
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Publ. Info: London : Academic Press
Pages: - Volume / Issue: 146 Sequence Number: 104419 Start / End Page: - Identifier: ISSN: 0195-6663
CoNE: https://pure.mpg.de/cone/journals/resource/954922648093