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  Emergence of a bilaterally symmetric pattern from chiral components in the planarian epidermis.

Basquin, C., Ershov, D., Gaudin, N., Vu, h. T. K., Louis, B., Papon, J. F., et al. (2019). Emergence of a bilaterally symmetric pattern from chiral components in the planarian epidermis. Developmental Cell, 51(4), 516-525. doi:10.1016/j.devcel.2019.10.021.

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Genre: Journal Article

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 Creators:
Basquin, C., Author
Ershov, D., Author
Gaudin, N., Author
Vu, h. T. K., Author
Louis, B., Author
Papon, J. F., Author
Orfila, A. M., Author
Mansour, Sarah, Author
Rink, J. C.1, Author              
Azimzadeh, J., Author
Affiliations:
1Department of Tissue Dynamics and Regeneration, MPI for Biophysical Chemistry, Max Planck Society, ou_3181978              

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 Abstract: Most animals exhibit mirror-symmetric body plans, yet the molecular constituents from which they are formed are often chiral. In planarian flatworms, centrioles are arranged in a bilaterally symmetric pattern across the ventral epidermis. Here, we found that this pattern is generated by a network of centrioles with prominent chiral asymmetric properties. We identify centriole components required for establishing asymmetric connections between centrioles and balancing their effects to align centrioles along polarity fields. SMED-ODF2, SMED-VFL1, and SMED-VFL3 affect the assembly of centriole appendages that tether cytoskeletal connectors to position the centrioles. We further show that the medio-lateral polarization of centrioles relies on mechanisms that are partly distinct on the left and right sides of the planarian body. Our findings shed light on how bilaterally symmetrical patterns can emerge from chiral cellular organizations.

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Language(s): eng - English
 Dates: 2019-11-182019-11-18
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.devcel.2019.10.021
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Title: Developmental Cell
Source Genre: Journal
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Pages: - Volume / Issue: 51 (4) Sequence Number: - Start / End Page: 516 - 525 Identifier: -