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  Newly formed and remodeled human bone exhibits differences in the mineralization process

Roschger, A., Wagermaier, W., Gamsjaeger, S., Hassler, N., Schmidt, I., Blouin, S., et al. (2020). Newly formed and remodeled human bone exhibits differences in the mineralization process. Acta Biomaterialia, 104, 221-230. doi:10.1016/j.actbio.2020.01.004.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0005-9C0B-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0007-4BD4-6
Genre: Journal Article

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 Creators:
Roschger, Andreas1, Author              
Wagermaier, Wolfgang1, Author              
Gamsjaeger, Sonja, Author
Hassler, Norbert, Author
Schmidt, Ingo1, Author              
Blouin, Stéphane, Author
Berzlanovich, Andrea, Author
Gruber, Gerlinde M., Author
Weinkamer, Richard2, Author              
Roschger, Paul, Author
Paschalis, Eleftherios P., Author
Klaushofer, Klaus, Author
Fratzl, Peter3, Author              
Affiliations:
1Wolfgang Wagermaier, Biomaterialien, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863296              
2Richard Weinkamer, Biomaterialien, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863295              
3Peter Fratzl, Biomaterialien, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863294              

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Free keywords: Bone mineralization, Crystal growth, Biomineralization, Mineralization pathway, Mineral transport
 Abstract: During human skeletal growth, bone is formed via different processes. Two of them are: new bone formation by depositing bone at the periosteal (outer) surface and bone remodeling corresponding to a local renewal of tissue. Since in remodeling formation is preceded by resorption, we hypothesize that modeling and remodeling could require radically different transport paths for ionic precursors of mineralization. While remodeling may recycle locally resorbed mineral, modeling implies the transport over large distances to the site of bone apposition. Therefore, we searched for potential differences of size, arrangement and chemical composition of mineral particles just below surfaces of modeling and remodeling sites in femur midshaft cross-sections from healthy children. These bone sites were mapped using scanning synchrotron X-ray scattering, Raman microspectroscopy, energy dispersive X-ray analysis and quantitative backscattered electron microscopy. The results show clear differences in mineral particle size and composition between the sites, which cannot be explained by a change in the rate of mineral apposition or accumulation. At periosteal modeling sites, mineral crystals are distinctly larger, display higher crystallinity and exhibit a lower calcium to phosphorus ratio and elevated Na and Mg content. The latter may originate from Mg used for phase stabilization of mineral precursors and therefore indicate different time periods for mineral transport. We conclude that the mineralization process is distinctively different between modeling and remodeling sites due to varying requirements for the transport distance and, therefore, the stability of non-crystalline ionic precursors, resulting in distinct compositions of the deposited mineral phase.

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Language(s): eng - English
 Dates: 2020-01-092020
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.actbio.2020.01.004
Other: M:\BM-Publications\2020\RoschgerActaBiomater_NewlyFormed
BibTex Citekey: ROSCHGER2020
PMID: 0582
 Degree: -

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Title: Acta Biomaterialia
  Other : Acta Biomater.
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 104 Sequence Number: - Start / End Page: 221 - 230 Identifier: ISSN: 1742-7061