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  Investigating microstructural variation in the human hippocampus using non-negative matrix factorization

Patel, R., Steele, C., Chen, A. G. X., Patel, S., Devenyi, G. A., Germann, J., et al. (2019). Investigating microstructural variation in the human hippocampus using non-negative matrix factorization. NeuroImage, 116348. doi:10.1016/j.neuroimage.2019.116348.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0005-848E-6 Version Permalink: http://hdl.handle.net/21.11116/0000-0005-A15C-E
Genre: Journal Article

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 Creators:
Patel, Raihaan1, 2, Author
Steele, Christopher1, 3, 4, Author              
Chen, Anthony G. X.1, 5, Author
Patel, Sejal1, 6, 7, Author
Devenyi, Gabriel A.1, 8, Author
Germann, Jürgen1, 9, Author
Tardif, Christine2, 10, 11, Author              
Chakravarty, M. Mallar1, 2, 8, Author
Affiliations:
1Cerebral Imaging Centre, Douglas Mental Health University Institute, McGill University, Montréal, QC, Canada, ou_persistent22              
2Department of Biomedical Engineering, Douglas Mental Health University Institute, McGill University, Montréal, QC, Canada, ou_persistent22              
3Department of Psychology, Concordia University, Montréal, QC, Canada, ou_persistent22              
4Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
5School of Computer Science, McGill University, Montréal, QC, Canada, ou_persistent22              
6Campbell Family Mental Health Research Institute, Department of Psychiatry, Centre for Addiction and Mental Health, University of Toronto, ON, USA, ou_persistent22              
7Institute of Medical Science, University of Toronto, ON, Canada, ou_persistent22              
8Department of Psychiatry, Douglas Mental Health University Institute, McGill University, Montréal, QC, Canada, ou_persistent22              
9University Health Network, University of Toronto, ON, Canada, ou_persistent22              
10McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montréal, QC, Canada, ou_persistent22              
11Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, Montréal, QC, Canada, ou_persistent22              

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Free keywords: Hippocampus; Microstructure; MRI; Multimodal; Non-negative matrix factorization
 Abstract: In this work we use non-negative matrix factorization to identify patterns of microstructural variance in the human hippocampus. We utilize high-resolution structural and diffusion magnetic resonance imaging data from the Human Connectome Project to query hippocampus microstructure on a multivariate, voxelwise basis. Application of non-negative matrix factorization identifies spatial components (clusters of voxels sharing similar covariance patterns), as well as subject weightings (individual variance across hippocampus microstructure). By assessing the stability of spatial components as well as the accuracy of factorization, we identified 4 distinct microstructural components. Furthermore, we quantified the benefit of using multiple microstructural metrics by demonstrating that using three microstructural metrics (T1-weighted/T2-weighted signal, mean diffusivity and fractional anisotropy) produced more stable spatial components than when assessing metrics individually. Finally, we related individual subject weightings to demographic and behavioural measures using a partial least squares analysis. Through this approach we identified interpretable relationships between hippocampus microstructure and demographic and behavioural measures. Taken together, our work suggests non-negative matrix factorization as a spatially specific analytical approach for neuroimaging studies and advocates for the use of multiple metrics for data-driven component analyses.

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Language(s): eng - English
 Dates: 2019-11-052019-08-262019-11-082019-11-09
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.neuroimage.2019.116348
Other: Epub ahead of print
PMID: 31715254
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Funding organization : Fonts de la Reserche du Quebec – Sante (FRQS)
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Funding organization : Canadian Institutes of Health Research (CIHR)
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Funding organization : Natural Sciences and Engineering Research Council of Canada (NSERC)
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Funding program : Shuk-Tak Liang Fellowship
Funding organization : McGill University
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Funding program : Human Connectome Project
Funding organization : National Institute of Health

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Title: NeuroImage
Source Genre: Journal
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Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: - Sequence Number: 116348 Start / End Page: - Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166