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  Body size-dependent energy storage causes Kleiber's law scaling of the metabolic rate in planarians.

Thommen, A., Werner, S., Frank, O., Philipp, J., Knittelfelder, O., Quek, Y., et al. (2019). Body size-dependent energy storage causes Kleiber's law scaling of the metabolic rate in planarians. eLife, 8: e38187. doi:10.7554/eLife.38187.

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Thommen, A., Author
Werner, S., Author
Frank, O., Author
Philipp, J., Author
Knittelfelder, O., Author
Quek, Y., Author
Fahmy, K., Author
Shevchenko, A., Author
Friedrich, B. M., Author
Jülicher, F., Author
Rink, J. C.1, Author              
Affiliations:
1Department of Tissue Dynamics and Regeneration, MPI for Biophysical Chemistry, Max Planck Society, ou_3181978              

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 Abstract: Kleiber's law, or the 3/4-power law scaling of the metabolic rate with body mass, is considered one of the few quantitative laws in biology, yet its physiological basis remains unknown. Here, we report Kleiber's law scaling in the planarian Schmidtea mediterranea. Its reversible and life history-independent changes in adult body mass over 3 orders of magnitude reveal that Kleiber's law does not emerge from the size-dependent decrease in cellular metabolic rate, but from a size-dependent increase in mass per cell. Through a combination of experiment and theoretical analysis of the organismal energy balance, we further show that the mass allometry is caused by body size dependent energy storage. Our results reveal the physiological origins of Kleiber's law in planarians and have general implications for understanding a fundamental scaling law in biology.

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Language(s): eng - English
 Dates: 2019-01-04
 Publication Status: Published online
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 Rev. Type: Peer
 Identifiers: DOI: 10.7554/eLife.38187
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Title: eLife
Source Genre: Journal
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Pages: 29 Volume / Issue: 8 Sequence Number: e38187 Start / End Page: - Identifier: -