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  Synthesis, physico-chemical properties and microsomal stability of compounds bearing aliphatic trifluoromethoxy group

Logvinenko, I. G., Markushyna, Y., Kondratov, I. S., Vashchenko, B. V., Kliachyna, M., Tokaryeva, Y., et al. (2020). Synthesis, physico-chemical properties and microsomal stability of compounds bearing aliphatic trifluoromethoxy group. Journal of Fluorine Chemistry, 231: 109461. doi:10.1016/j.jfluchem.2020.109461.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0005-9BF3-A Version Permalink: http://hdl.handle.net/21.11116/0000-0005-E913-F
Genre: Journal Article

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 Creators:
Logvinenko, Ivan G., Author
Markushyna, Yevheniia1, Author              
Kondratov, Ivan S., Author
Vashchenko, Bohdan V., Author
Kliachyna, Maria, Author
Tokaryeva, Yuliya, Author
Pivnytska, Valentyna, Author
Grygorenko, Oleksandr O., Author
Haufe, Günter, Author
Affiliations:
1Aleksandr Savateev, Kolloidchemie, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_2421702              

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Free keywords: Aliphatic compounds, Trifluoromethoxy group, Lipophilicity, Microsomal stability
 Abstract: Effects of the trifluoromethoxy substituent on physico-chemical properties of compounds, such as kinetic solubility, lipophilicity and microsomal clearance, was studied in a series of aliphatic derivatives. It was found that kinetic solubility of the CF3O-containing compounds was comparable to that of analogs, i.e. compounds bearing CH3O and CF3 moieties. The CF3O-substituted compounds had higher lipophilicity as compared to methoxy analogues, and nearly the same like CF3-bearing compounds. Microsomal stability studies indicated that the trifluoromethoxy group typically decreased metabolic stability of the corresponding derivatives as compared to either CH3O- or CF3-substituted counterparts, except for N-alkoxy(sulfon)amide series.

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Language(s): eng - English
 Dates: 2020-01-172020
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.jfluchem.2020.109461
Other: PDF angefordert 5.2.20 SN
BibTex Citekey: LOGVINENKO2020109461
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Title: Journal of Fluorine Chemistry
  Other : J. Fluor. Chem.
Source Genre: Journal
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Publ. Info: Lausanne : Elsevier
Pages: - Volume / Issue: 231 Sequence Number: 109461 Start / End Page: - Identifier: ISSN: 0022-1139