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  Cytoskeletal and Actin-Based Polymerization Motors and Their Role in Minimal Cell Design

Hürtgen, D., Vogel, S. K., & Schwille, P. (2019). Cytoskeletal and Actin-Based Polymerization Motors and Their Role in Minimal Cell Design. Advanced Biosystems, 3(6, SI): 1800311. doi:10.1002/adbi.201800311.

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Genre: Journal Article
Other : Review

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 Creators:
Hürtgen, Daniel1, Author
Vogel, Sven Kenjiro2, Author              
Schwille, Petra2, Author              
Affiliations:
1external, ou_persistent22              
2Schwille, Petra / Cellular and Molecular Biophysics, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565169              

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Free keywords: FILAMENT BARBED ENDS; LISTERIA-MONOCYTOGENES; SELF-ORGANIZATION; DNA SEGREGATION; CORTICAL FLOW; 2 DISTINCT; RECONSTITUTION; MECHANICS; NETWORKS; MREBMaterials Science; actin; cytoskeleton; in vitro reconstitution; minimal cell; molecular machines; molecular motors; synthetic biology;
 Abstract: Life implies motion. In cells, protein-based active molecular machines drive cell locomotion and intracellular transport, control cell shape, segregate genetic material, and split a cell in two parts. Key players among molecular machines driving these various cell functions are the cytoskeleton and motor proteins that convert chemical bound energy into mechanical work. Findings over the last decades in the field of in vitro reconstitutions of cytoskeletal and motor proteins have elucidated mechanistic details of these active protein systems. For example, a complex spatial and temporal interplay between the cytoskeleton and motor proteins is responsible for the translation of chemically bound energy into (directed) movement and force generation, which eventually governs the emergence of complex cellular functions. Understanding these mechanisms and the design principles of the cytoskeleton and motor proteins builds the basis for mimicking fundamental life processes. Here, a brief overview of actin, prokaryotic actin analogs, and motor proteins and their potential role in the design of a minimal cell from the bottom-up is provided.

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Language(s): eng - English
 Dates: 20192019
 Publication Status: Published in print
 Pages: 11
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: ISI: 000471702000003
DOI: 10.1002/adbi.201800311
 Degree: -

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Title: Advanced Biosystems
  Other : Special Issue: Cynthetic Cells
Source Genre: Journal
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Publ. Info: Weinheim : Wiley-VCH
Pages: - Volume / Issue: 3 (6, SI) Sequence Number: 1800311 Start / End Page: - Identifier: ISSN: 2366-7478
CoNE: https://pure.mpg.de/cone/journals/resource/2366-7478