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  The exonuclease Xrn1 activates transcription and translation of mRNAs encoding membrane proteins

Blasco-Moreno, B., de Campos-Mata, L., Bottcher, R., Garcia-Martinez, J., Jungfleisch, J., Nedialkova, D. D., et al. (2019). The exonuclease Xrn1 activates transcription and translation of mRNAs encoding membrane proteins. NATURE COMMUNICATIONS, 10: 1298. doi:10.1038/s41467-019-09199-6.

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 Creators:
Blasco-Moreno, Bernat1, Author
de Campos-Mata, Leire1, Author
Bottcher, Rene1, Author
Garcia-Martinez, Jose1, Author
Jungfleisch, Jennifer1, Author
Nedialkova, Danny D.2, Author              
Chattopadhyay, Shiladitya1, Author
Gas, Maria-Eugenia1, Author
Oliva, Baldomero1, Author
Perez-Ortin, Jose E.1, Author
Leidel, Sebastian A.1, Author
Choder, Mordechai1, Author
Diez, Juana1, Author
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1external, ou_persistent22              
2Nedialkova, Danny / Mechanisms of Protein Biogenesis, Max Planck Institute of Biochemistry, Max Planck Society, ou_2466698              

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Free keywords: SACCHAROMYCES-CEREVISIAE; GENE-EXPRESSION; IN-VIVO; YEAST; DEGRADATION; REPLICATION; DECAY; EXORIBONUCLEASE; INITIATION; MUTATIONSScience & Technology - Other Topics;
 Abstract: The highly conserved 5'-3' exonuclease Xrn1 regulates gene expression in eukaryotes by coupling nuclear DNA transcription to cytosolic mRNA decay. By integrating transcriptome-wide analyses of translation with biochemical and functional studies, we demonstrate an unanticipated regulatory role of Xrn1 in protein synthesis. Xrn1 promotes translation of a specific group of transcripts encoding membrane proteins. Xrnl-dependence for translation is linked to poor structural RNA contexts for translation initiation, is mediated by interactions with components of the translation initiation machinery and correlates with an Xrnl-dependence for mRNA localization at the endoplasmic reticulum, the translation compartment of membrane proteins. Importantly, for this group of mRNAs, Xrn1 stimulates transcription, mRNA translation and decay. Our results uncover a crosstalk between the three major stages of gene expression coordinated by Xrn1 to maintain appropriate levels of membrane proteins.

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Language(s): eng - English
 Dates: 2019
 Publication Status: Published online
 Pages: 15
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
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Title: NATURE COMMUNICATIONS
Source Genre: Journal
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Publ. Info: MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND : NATURE PUBLISHING GROUP
Pages: - Volume / Issue: 10 Sequence Number: 1298 Start / End Page: - Identifier: ISSN: 2041-1723