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  The genome of Schmidtea mediterranea and the evolution of core cellular mechanisms.

Grohme, M. A., Schloissnig, S., Rozanski, A., Pippel, M., Young, G. R., Winkler, S., et al. (2018). The genome of Schmidtea mediterranea and the evolution of core cellular mechanisms. Nature, 554(7690), 56-61. doi:10.1038/nature25473.

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 Creators:
Grohme, M. A., Author
Schloissnig, S., Author
Rozanski, A.1, Author              
Pippel, M., Author
Young, G. R., Author
Winkler, S., Author
Brandl, H., Author
Dahl, A., Author
Powell, S., Author
Hiller, M., Author
Myers, E., Author
Rink, J. C.1, Author              
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1Department of Tissue Dynamics and Regeneration, MPI for Biophysical Chemistry, Max Planck Society, ou_3181978              

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 Abstract: The planarian Schmidtea mediterranea is an important model for stem cell research and regeneration, but adequate genome resources for this species have been lacking. Here we report a highly contiguous genome assembly of S. mediterranea, using long-read sequencing and a de novo assembler (MARVEL) enhanced for low-complexity reads. The S. mediterranea genome is highly polymorphic and repetitive, and harbours a novel class of giant retroelements. Furthermore, the genome assembly lacks a number of highly conserved genes, including critical components of the mitotic spindle assembly checkpoint, but planarians maintain checkpoint function. Our genome assembly provides a key model system resource that will be useful for studying regeneration and the evolutionary plasticity of core cell biological mechanisms.

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Language(s): eng - English
 Dates: 2018-01-242018
 Publication Status: Published in print
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 Rev. Type: Peer
 Identifiers: DOI: 10.1038/nature25473
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Title: Nature
Source Genre: Journal
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Pages: - Volume / Issue: 554 (7690) Sequence Number: - Start / End Page: 56 - 61 Identifier: -