English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  A dynamically diluted alignment model reveals the impact of cell turnover on the plasticity of tissue polarity patterns.

Hoffmann, K. B., Voss-Böhme, A., Rink, J. C., & Brusch, L. (2017). A dynamically diluted alignment model reveals the impact of cell turnover on the plasticity of tissue polarity patterns. Journal of the Royal Society Interface, 14(135): 20170466. doi:10.1098/rsif.2017.0466.

Item is

Basic

show hide
Genre: Journal Article

Files

show Files
hide Files
:
3190193.pdf (Publisher version), 2MB
 
File Permalink:
-
Name:
3190193.pdf
Description:
-
Visibility:
Restricted ( Max Planck Society (every institute); )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-
:
3190193_Suppl.htm (Supplementary material), 45KB
Name:
3190193_Suppl.htm
Description:
-
Visibility:
Public
MIME-Type / Checksum:
text/html / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Hoffmann, K. B., Author
Voss-Böhme, A., Author
Rink, J. C.1, Author              
Brusch, L., Author
Affiliations:
1Department of Tissue Dynamics and Regeneration, MPI for Biophysical Chemistry, Max Planck Society, ou_3181978              

Content

show
hide
Free keywords: mathematical biology; planar cell polarity; planaria; regeneration; interacting particle system; mean-field analysis
 Abstract: The polarization of cells and tissues is fundamental for tissue morphogenesis during biological development and regeneration. A deeper understanding of biological polarity pattern formation can be gained from the consideration of pattern reorganization in response to an opposing instructive cue, which we here consider using the example of experimentally inducible body axis inversions in planarian flatworms. We define a dynamically diluted alignment model linking three processes: entrainment of cell polarity by a global signal, local cell-cell coupling aligning polarity among neighbours, and cell turnover replacing polarized cells by initially unpolarized cells. We show that a persistent global orienting signal determines the final mean polarity orientation in this stochastic model. Combining numerical and analytical approaches, we find that neighbour coupling retards polarity pattern reorganization, whereas cell turnover accelerates it. We derive a formula for an effective neighbour coupling strength integrating both effects and find that the time of polarity reorganization depends linearly on this effective parameter and no abrupt transitions are observed. This allows us to determine neighbour coupling strengths from experimental observations. Our model is related to a dynamic 8-Potts model with annealed site-dilution and makes testable predictions regarding the polarization of dynamic systems, such as the planarian epithelium.

Details

show
hide
Language(s): eng - English
 Dates: 2017-10-042017
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1098/rsif.2017.0466
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Journal of the Royal Society Interface
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: 14 Volume / Issue: 14 (135) Sequence Number: 20170466 Start / End Page: - Identifier: -