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  T2 relaxation times of macromolecules and metabolites in the human brain at 9.4 T

Murali-Manohar, S., Borbath, T., Wright, A., Soher, B., Mekle, R., & Henning, A. (2020). T2 relaxation times of macromolecules and metabolites in the human brain at 9.4 T. Magnetic Resonance in Medicine, 84(2), 542-558. doi:10.1002/mrm.28174.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0005-94EC-A Version Permalink: http://hdl.handle.net/21.11116/0000-0006-4380-D
Genre: Journal Article

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Murali-Manohar, S1, 2, Author              
Borbath, T1, 2, Author              
Wright, AM1, 2, Author              
Soher, B, Author
Mekle, R, Author
Henning, A1, 2, Author              
Affiliations:
1Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528692              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: PURPOSE: Relaxation times can contribute to spectral assignment. In this study, effective T2 relaxation times ( Teff2 ) of macromolecules are reported for gray and white matter-rich voxels in the human brain at 9.4 T. The Teff2 of macromolecules are helpful to understand their behavior and the effect they have on metabolite quantification. Additionally, for absolute quantification of metabolites with magnetic resonance spectroscopy, appropriate T2 values of metabolites must be considered. The T2 relaxation times of metabolites are calculated after accounting for TE/sequence-specific macromolecular baselines. METHODS: Macromolecular and metabolite spectra for a series of TEs were acquired at 9.4 T using double inversion-recovery metabolite-cycled semi-LASER and metabolite-cycled semi-LASER, respectively. The T2 relaxation times were calculated by fitting the LCModel relative amplitudes of macromolecular peaks and metabolites to a mono-exponential decay across the TE series. Furthermore, absolute concentrations of metabolites were calculated using the estimated relaxation times and internal water as reference. RESULTS: The Teff2 of macromolecules are reported, which range from 13 ms to 40 ms, whereas, for metabolites, they range from 40 ms to 110 ms. Both macromolecular and metabolite T2 relaxation times are observed to follow the decreasing trend, with increasing B0 . The linewidths of metabolite singlets can be fully attributed to T2 and B0 components. However, in addition to these components, macromolecule linewidths have contributions from J-coupling and overlapping resonances. CONCLUSION: The T2 relaxation times of all macromolecular and metabolite peaks at 9.4 T in vivo are reported for the first time. Metabolite relaxation times were used to calculate the absolute metabolite concentrations.

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 Dates: 2020-012020-08
 Publication Status: Published in print
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 Identifiers: DOI: 10.1002/mrm.28174
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Title: Magnetic Resonance in Medicine
Source Genre: Journal
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Publ. Info: New York : Wiley-Liss
Pages: - Volume / Issue: 84 (2) Sequence Number: - Start / End Page: 542 - 558 Identifier: ISSN: 0740-3194
CoNE: https://pure.mpg.de/cone/journals/resource/954925538149