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  A study on the pharmacokinetics in mouse of adenine-9-beta-D-arabinofuranoside 5-monophosphate conjugated with lactosaminated albumin

Fiume, L., Bassi, B., Busi, C., Mattioli, A., & Wieland, T. (1985). A study on the pharmacokinetics in mouse of adenine-9-beta-D-arabinofuranoside 5-monophosphate conjugated with lactosaminated albumin. Experientia: interdisciplinary journal for the life sciences, 41(10), 1326-1328. doi:10.1007/BF01952078.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0005-9963-F Version Permalink: http://hdl.handle.net/21.11116/0000-0005-9964-E
Genre: Journal Article

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Experientia_41_1985_1326.pdf (Any fulltext), 345KB
 
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 Creators:
Fiume, L.1, Author              
Bassi , B., Author
Busi, C., Author
Mattioli, A., Author
Wieland, Theodor1, Author              
Affiliations:
1Max Planck Institute for Medical Research, Max Planck Society, ou_1125545              

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Free keywords: Adenine arabinoside 5-monophosphate, drug targeting, hepatitis B
 Abstract: In plasma of mice injected with adenine-9-beta-D-arabinofuranoside monophosphate (ara-AMP) coupled to human lactosaminated serum albumin (L-HSA) some of the ara-AMP molecules are enzymatically released, whereas others remain linked to L-HSA. Evidence has been obtained that ara-AMP is not deaminated when it is conjugated to L-HSA, in contrast to the free drug which is rapidly metabolized to its hypoxanthine derivative.

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Language(s): eng - English
 Dates: 1984-06-251985-10
 Publication Status: Published in print
 Pages: 3
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Degree: -

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Title: Experientia: interdisciplinary journal for the life sciences
Source Genre: Journal
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Publ. Info: Basel; Berlin [u.a.] : Birkhäuser
Pages: - Volume / Issue: 41 (10) Sequence Number: - Start / End Page: 1326 - 1328 Identifier: ISSN: 0014-4754
CoNE: https://pure.mpg.de/cone/journals/resource/0014-4754