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  CpG-Loaded Multifunctional Cationic Nanohydrogel Particles as Self-Adjuvanting Glycopeptide Antitumor Vaccines

Hartmann, S., Nuhn, L., Palitzsch, B., Glaffig, M., Stergiou, N., Gerlitzki, B., et al. (2015). CpG-Loaded Multifunctional Cationic Nanohydrogel Particles as Self-Adjuvanting Glycopeptide Antitumor Vaccines. Advanced Healthcare Materials, 4(4), 522-527. doi:10.1002/adhm.201400460.

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Genre: Journal Article

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 Creators:
Hartmann, Sebastian, Author
Nuhn, Lutz1, Author           
Palitzsch, Björn, Author
Glaffig, Markus, Author
Stergiou, Natascha, Author
Gerlitzki, Bastian, Author
Schmitt, Edgar, Author
Kunz, Horst, Author
Zentel, Rudolf, Author
Affiliations:
1Johannes Gutenberg Univ Mainz, Inst Organ Chem, Mainz, Germany, ou_persistent22              

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Free keywords: anti-tumor vaccines, cationic nanohydrogels, CpG codelivery, MUC1 glycopeptide, self-adjuvanting vaccines
 Abstract: Self-adjuvanting antitumor vaccines by multifunctional cationic ­nanohydrogels loaded with CpG. A conjugate ­consisting of tumor-associated MUC1-glycopeptide B-cell epitope and tetanus toxin ­T-cell epitope P2 is linked to cationic nanogels. Oligonucleotide CpG complexation enhances toll-like receptor (TLR) stimulated T-cell proliferation and rapid immune activation. This co-delivery promotes induction of specific MUC1-antibodies binding to human breast ­tumor cells without external adjuvant.

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Language(s): eng - English
 Dates: 2015
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1002/adhm.201400460
BibTex Citekey: doi:10.1002/adhm.201400460
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Title: Advanced Healthcare Materials
Source Genre: Journal
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Affiliations:
Publ. Info: Wiley-VCH
Pages: - Volume / Issue: 4 (4) Sequence Number: - Start / End Page: 522 - 527 Identifier: ISSN: 2192-2640
CoNE: https://pure.mpg.de/cone/journals/resource/2192-2640