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  Water-Soluble Polymers Coupled with Glycopeptide Antigens and T-Cell Epitopes as Potential Antitumor Vaccines

Nuhn, L., Hartmann, S., Palitzsch, B., Gerlitzki, B., Schmitt, E., Zentel, R., et al. (2013). Water-Soluble Polymers Coupled with Glycopeptide Antigens and T-Cell Epitopes as Potential Antitumor Vaccines. Angewandte Chemie, International Edition, 52(40), 10652-10656. doi:10.1002/anie.201304212.

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Genre: Journal Article

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 Creators:
Nuhn, Lutz1, Author           
Hartmann, Sebastian, Author
Palitzsch, Björn, Author
Gerlitzki, Bastian, Author
Schmitt, Edgar, Author
Zentel, Rudolf, Author
Kunz, Horst, Author
Affiliations:
1Johannes Gutenberg Univ Mainz, Inst Organ Chem, Mainz, Germany, ou_persistent22              

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Free keywords: antitumor vaccines, HPMA, MUC1 glycopeptides, polymer glycopeptide conjugates, T-helper-cell epitope peptides
 Abstract: Highly decorated: Tumor-associated MUC1 glycopeptide and tetanus toxoid T-cell epitope P2 can be attached to water-soluble poly(N-(2-hydroxypropyl)methacrylamide) carriers by orthogonal ligation techniques. Fully synthetic vaccine A with additional nanostructure-promoting domains induced antibodies that exhibit high affinity to tumor cells.

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Language(s): eng - English
 Dates: 2013
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1002/anie.201304212
BibTex Citekey: doi:10.1002/anie.201304212
 Degree: -

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Title: Angewandte Chemie, International Edition
  Abbreviation : Angew. Chem., Int. Ed.
Source Genre: Journal
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Publ. Info: Weinheim : Wiley-VCH
Pages: - Volume / Issue: 52 (40) Sequence Number: - Start / End Page: 10652 - 10656 Identifier: ISSN: 1433-7851
CoNE: https://pure.mpg.de/cone/journals/resource/1433-7851