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  Water-Dispersible and Biocompatible Iron Carbide Nanoparticles with High Specific Absorption Rate

Bordet, A., Landis, R. F., Lee, Y., Tonga, G. Y., Asensio, J. M., Li, C.-H., et al. (2019). Water-Dispersible and Biocompatible Iron Carbide Nanoparticles with High Specific Absorption Rate. ACS Nano, 13(3), 2870-2878. doi:10.1021/acsnano.8b05671.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0005-A9D5-C Version Permalink: http://hdl.handle.net/21.11116/0000-0005-A9D6-B
Genre: Journal Article

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 Creators:
Bordet, Alexis1, Author              
Landis, Ryan F., Author
Lee, Yiwei, Author
Tonga, Gulen Y., Author
Asensio, Juan M., Author
Li, Cheng-Hsuan, Author
Fazzini, Pier-Francesco, Author
Soulantica, Katerina, Author
Rotello, Vincent M., Author
Chaudret, Bruno, Author
Affiliations:
1Research Department Leitner, Max Planck Institute for Chemical Energy Conversion, Max Planck Society, ou_3023872              

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 Abstract: Magnetic nanoparticles are important tools for biomedicine, where they serve as versatile multifunctional instruments for a wide range of applications. Among these applications, magnetic hyperthermia is of special interest for the destruction of tumors and triggering of drug delivery. However, many applications of magnetic nanoparticles require high-quality magnetic nanoparticles displaying high specific absorption rates (SARs), which remains a challenge today. We report here the functionalization and stabilization in aqueous media of highly magnetic 15 nm iron carbide nanoparticles featuring excellent heating power through magnetic induction. The challenge of achieving water solubility and colloidal stability was addressed by designing and using specific dopamine-based ligands. The resulting nanoparticles were completely stable for several months in water, phosphate, phosphate-buffered saline, and serum-containing media. Iron carbide nanoparticles displayed high SARs in water and viscous media (water/glycerol mixtures), even after extended exposition to water and oxygen (SAR up to 1000 W.g(-1) in water at 100 kHz, 47 mT). The cytotoxicity and cellular uptake of iron carbide nanoparticles could be easily tuned and were highly dependent on the chemical structure of the ligands used.

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Language(s): eng - English
 Dates: 2019
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: ISI: 000462950500016
DOI: 10.1021/acsnano.8b05671
 Degree: -

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Title: ACS Nano
  Other : ACS Nano
Source Genre: Journal
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Publ. Info: Washington, DC : American Chemical Society
Pages: - Volume / Issue: 13 (3) Sequence Number: - Start / End Page: 2870 - 2878 Identifier: ISSN: 1936-0851
CoNE: https://pure.mpg.de/cone/journals/resource/1936-0851