English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Evolutionary change in physiological phenotypes along the human lineage

Vining, A. Q., & Nunn, C. L. (2016). Evolutionary change in physiological phenotypes along the human lineage. Evolution, Medicine and Public Health, (1), 312-324. doi:10.1093/emph/eow026.

Item is

Basic

show hide
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Vining, Alexander Q.1, Author              
Nunn, C. L., Author
Affiliations:
1Duke University, ou_persistent22              

Content

show
hide
Free keywords: -
 Abstract: Background and Objectives: Research in evolutionary medicine provides many examples of how evolution has shaped human susceptibility to disease. Traits undergoing rapid evolutionary change may result in associated costs or reduce the energy available to other traits. We hypothesize that humans have experienced more such changes than other primates as a result of major evolutionary change along the human lineage. We investigated 41 physiological traits across 50 primate species to identify traits that have undergone marked evolutionary change along the human lineage. Methodology: We analysed the data using two Bayesian phylogenetic comparative methods. One approach models trait covariation in non-human primates and predicts human phenotypes to identify whether humans are evolutionary outliers. The other approach models adaptive shifts under an Ornstein-Uhlenbeck model of evolution to assess whether inferred shifts are more common on the human branch than on other primate lineages. Results: We identified four traits with strong evidence for an evolutionary increase on the human lineage (amylase, haematocrit, phosphorus and monocytes) and one trait with strong evidence for decrease (neutrophilic bands). Humans exhibited more cases of distinct evolutionary change than other primates. Conclusions and Implications: Human physiology has undergone increased evolutionary change compared to other primates. Long distance running may have contributed to increases in haematocrit and mean corpuscular haemoglobin concentration, while dietary changes are likely related to increases in amylase. In accordance with the pathogen load hypothesis, human monocyte levels were increased, but many other immune-related measures were not. Determining the mechanisms underlying conspicuous evolutionary change in these traits may provide new insights into human disease.

Details

show
hide
Language(s):
 Dates: 2016-09-11
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: Other: WOS:000385925600029
DOI: 10.1093/emph/eow026
ISSN: 2050-6201
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Evolution, Medicine and Public Health
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: United Kingdom : Oxford University Press
Pages: - Volume / Issue: (1) Sequence Number: - Start / End Page: 312 - 324 Identifier: CoNE: https://pure.mpg.de/cone/journals/resource/2050-6201