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  The mid-developmental transition and the evolution of animal body plans.

Levin, M., Anavy, L., Cole, A. G., Winter, E., Mostov, N., Khair, S., et al. (2016). The mid-developmental transition and the evolution of animal body plans. Nature, 531(7596), 637-641. doi:10.1038/nature16994.

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 Creators:
Levin, M., Author
Anavy, L., Author
Cole, A. G., Author
Winter, E., Author
Mostov, N., Author
Khair, S., Author
Senderovich, N., Author
Kovalev, E., Author
Silver, D. H., Author
Feder, M., Author
Fernandez-Valverde, S. L., Author
Nakanishi, N., Author
Simmons, D., Author
Simakov, O., Author
Larsson, T., Author
Liu, S. Y., Author
Jerafi-Vider, A., Author
Yaniv, K., Author
Ryan, J. F., Author
Martindale, M. Q., Author
Rink, J. C.1, Author              Arendt, D., AuthorDegnan, S. M., AuthorDegnan, B. M., AuthorHashimshony, T., AuthorYanai, I., Author more..
Affiliations:
1Department of Tissue Dynamics and Regeneration, MPI for Biophysical Chemistry, Max Planck Society, ou_3181978              

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 Abstract: Animals are grouped into similar to 35 'phyla' based upon the notion of distinct body plans(1-4). Morphological and molecular analyses have revealed that a stage in the middle of development-known as the phylotypic period-is conserved among species within some phyla(5-9). Although these analyses provide evidence for their existence, phyla have also been criticized as lacking an objective definition, and consequently based on arbitrary groupings of animals(10). Here we compare the developmental transcriptomes of ten species, each annotated to a different phylum, with a wide range of life histories and embryonic forms. We find that in all ten species, development comprises the coupling of early and late phases of conserved gene expression. These phases are linked by a divergent 'mid-developmental transition' that uses species-specific suites of signalling pathways and transcription factors. This mid-developmental transition overlaps with the phylotypic period that has been defined previously for three of the ten phyla, suggesting that transcriptional circuits and signalling mechanisms active during this transition are crucial for defining the phyletic body plan and that the mid-developmental transition may be used to define phylotypic periods in other phyla. Placing these observations alongside the reported conservation of mid-development within phyla, we propose that a phylum may be defined as a collection of species whose gene expression at the mid-developmental transition is both highly conserved among them, yet divergent relative to other species.

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Language(s): eng - English
 Dates: 2016-02-172016
 Publication Status: Published in print
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 Rev. Type: Peer
 Identifiers: DOI: 10.1038/nature16994
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Title: Nature
Source Genre: Journal
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Pages: - Volume / Issue: 531 (7596) Sequence Number: - Start / End Page: 637 - 641 Identifier: -