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  Orbitofrontal cortex: A neural circuit for economic decisions

Padoa-Schioppa, C., & Conen, K. E. (2017). Orbitofrontal cortex: A neural circuit for economic decisions. Neuron, 96(4), 736-754. doi:10.1016/j.neuron.2017.09.031.

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Padoa-Schioppa, C., Author
Conen, Katherine E.1, Author              
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1Washington University in St. Louis, ou_persistent22              

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 Abstract: Economic choice behavior entails the computation and comparison of subjective values. A central contribution of neuroeconomics has been to show that subjective values are represented explicitly at the neuronal level. With this result at hand, the field has increasingly focused on the difficult question of where in the brain and how exactly subjective values are compared to make a decision. Here, we review a broad range of experimental and theoretical results suggesting that good-based decisions are generated in a neural circuit within the orbitofrontal cortex (OFC). The main lines of evidence supporting this proposal include the fact that goal-directed behavior is specifically disrupted by OFC lesions, the fact that different groups of neurons in this area encode the input and the output of the decision process, the fact that activity fluctuations in each of these cell groups correlate with choice variability, and the fact that these groups of neurons are computationally sufficient to generate decisions. Results from other brain regions are consistent with the idea that good-based decisions take place in OFC and indicate that value signals inform a variety of mental functions. We also contrast the present proposal with other leading models for the neural mechanisms of economic decisions. Finally, we indicate open questions and suggest possible directions for future research.

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 Dates: 2017-11-15
 Publication Status: Published in print
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 Identifiers: Other: WOS:000415310800008
DOI: 10.1016/j.neuron.2017.09.031
ISSN: 0896-6273
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Title: Neuron
Source Genre: Journal
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Publ. Info: Cambridge, Mass. : Cell Press
Pages: - Volume / Issue: 96 (4) Sequence Number: - Start / End Page: 736 - 754 Identifier: ISSN: 0896-6273
CoNE: https://pure.mpg.de/cone/journals/resource/954925560565