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  Resolving multisensory and attentional influences across cortical depth in sensory cortices

Gau, R., Bazin, P.-L., Trampel, R., Turner, R., & Noppeney, U. (2020). Resolving multisensory and attentional influences across cortical depth in sensory cortices. eLife, 9: e46856. doi:10.7554/eLife.46856.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0005-A491-D Version Permalink: http://hdl.handle.net/21.11116/0000-0005-AC0F-A
Genre: Journal Article

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 Creators:
Gau, Remi1, 2, 3, Author
Bazin, Pierre-Louis4, 5, Author              
Trampel, Robert4, Author              
Turner, Robert6, 7, Author              
Noppeney, Uta1, 8, Author
Affiliations:
1Computational Neuroscience and Cognitive Robotics Centre, University of Birmingham, United Kingdom, ou_persistent22              
2Faculty of Psychology and Educational Sciences, Université Catholique de Louvain, Belgium, ou_persistent22              
3Institute of Neuroscience, Université Catholique de Louvain, Belgium, ou_persistent22              
4Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              
5Integrative Model-Based Cognitive Neuroscience Research Unit (IMCN), University of Amsterdam, the Netherlands, ou_persistent22              
6Sir Peter Mansfield Magnetic Resonance Centre, University of Nottingham, United Kingdom, ou_persistent22              
7Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634550              
8Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands, ou_persistent22              

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Free keywords: Audiovisual; Cortical layers; Crossmodal attention; Deactivations; Human; Multisensory integration; Neuroscience; Primary sensory cortices
 Abstract: In our environment our senses are bombarded with a myriad of signals, only a subset of which is relevant for our goals. Using sub-millimeter-resolution fMRI at 7T we resolved BOLD-response and activation patterns across cortical depth in early sensory cortices to auditory, visual and audiovisual stimuli under auditory or visual attention. In visual cortices, auditory stimulation induced widespread inhibition irrespective of attention, whereas auditory relative to visual attention suppressed mainly central visual field representations. In auditory cortices, visual stimulation suppressed activations, but amplified responses to concurrent auditory stimuli, in a patchy topography. Critically, multisensory interactions in auditory cortices were stronger in deeper laminae, while attentional influences were greatest at the surface. These distinct depth-dependent profiles suggest that multisensory and attentional mechanisms regulate sensory processing via partly distinct circuitries. Our findings are crucial for understanding how the brain regulates information flow across senses to interact with our complex multisensory world.

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Language(s): eng - English
 Dates: 2019-03-142020-01-072020-01-08
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.7554/eLife.46856
PMC: PMC6984812
PMID: 31913119
 Degree: -

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Title: eLife
Source Genre: Journal
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Publ. Info: Cambridge : eLife Sciences Publications
Pages: - Volume / Issue: 9 Sequence Number: e46856 Start / End Page: - Identifier: ISSN: 2050-084X
CoNE: https://pure.mpg.de/cone/journals/resource/2050-084X