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  Morphine withdrawal increases expression of GABAA receptor subunit mRNA in locus coeruleus neurons

Heikkilä, A., Echenko, O., Uusi-Oukari, M., Sinkkonen, S., & Korpi, E. (2001). Morphine withdrawal increases expression of GABAA receptor subunit mRNA in locus coeruleus neurons. NeuroReport, 12(13), 2981-2985. doi:10.1097/00001756-200109170-00045.

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Heikkilä, AT, Author
Echenko, O1, Author              
Uusi-Oukari, M, Author
Sinkkonen, ST, Author
Korpi, ER, Author
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1External Organizations, ou_persistent22              

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 Abstract: An increase in the activity of brain stem locus coeruleus noradrenergic neurons has been hypothesised to be a major factor accounting for opiate withdrawal symptoms. These neurons are under GABAergic inhibition. Their GABAA receptors have unique pharmacological properties, most likely due to the enriched expression of GABAA receptor subtypes containing novel ∊ and θ subunits. Using in situ hybridisation of cryostat sections, we now report a significant increase in the ∊ subunit mRNA expression after precipitation of opioid withdrawal by naloxone. Similar changes were detected in tyrosine hydroxylase mRNA expression. The results suggest increased formation of unique GABAA receptor subtype(s) in the locus coeruleus neurons during increased neuronal activity.

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 Dates: 2001-09
 Publication Status: Published in print
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Title: NeuroReport
Source Genre: Journal
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Publ. Info: Oxford, UK : Rapid Communications of Oxford Ltd.
Pages: - Volume / Issue: 12 (13) Sequence Number: - Start / End Page: 2981 - 2985 Identifier: ISSN: 0959-4965
CoNE: https://pure.mpg.de/cone/journals/resource/954925578070