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  Respiratory complex I - structure, mechanism and evolution

Parey, K. K., Wirth, C., Vonck, J., & Zickermann, V. (2020). Respiratory complex I - structure, mechanism and evolution. Current Opinion in Structural Biology, 63. doi:10.1016/j.sbi.2020.01.004.

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 Creators:
Parey, Kristian Kurt1, 2, 3, Author           
Wirth, Christophe4, Author
Vonck, Janet1, Author           
Zickermann, Volker2, 3, Author
Affiliations:
1Department of Structural Biology, Max Planck Institute of Biophysics, Max Planck Society, ou_2068291              
2Institute of Biochemistry II, University Hospital, Goethe University, Frankfurt am Main, Germany, ou_persistent22              
3Centre for Biomolecular Magnetic Resonance, Institute for Biophysical Chemistry, Goethe University, Frankfurt am Main, Germany, ou_persistent22              
4Institute of Biochemistry and Molecular Biology, ZBMZ, Medical Faculty, Albert-Ludwigs-University Freiburg, Freiburg, Germany, ou_persistent22              

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 Abstract: Respiratory complex I is an intricate multi-subunit membrane protein with a central function in aerobic energy metabolism. During the last years, structures of mitochondrial complex I and respiratory supercomplexes were determined by cryo-EM at increasing resolution. Structural and computational studies have shed light on the dynamics of proton translocation pathways, the interaction of complex I with lipids and the unusual access pathway of ubiquinone to the active site. Recent advances in understanding complex I function include characterization of specific conformational changes that are critical for proton pumping. Cryo-EM structures of the NADH dehydrogenase-like (NDH) complex of photosynthesis and a bacterial membrane bound hydrogenase (MBH) have provided a broader perspective on the complex I superfamily.

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Language(s): eng - English
 Dates: 2020-02-102020-08
 Publication Status: Published in print
 Pages: 9
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.sbi.2020.01.004
BibTex Citekey: parey_respiratory_2020
 Degree: -

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Title: Current Opinion in Structural Biology
  Other : Curr. Opin. Struct. Biol.
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 63 Sequence Number: - Start / End Page: - Identifier: ISSN: 0959-440X
CoNE: https://pure.mpg.de/cone/journals/resource/954925578067