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  A preclinical large-animal model for the assessment of critical-size load-bearing bone defect reconstruction

Sparks, D. S., Saifzadeh, S., Savi, F. M., Dlaska, C. E., Berner, A., Henkel, J., et al. (2020). A preclinical large-animal model for the assessment of critical-size load-bearing bone defect reconstruction. Nature Protocols, 15(3), 877-924. doi:10.1038/s41596-019-0271-2.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0005-AADF-1 Version Permalink: http://hdl.handle.net/21.11116/0000-0005-DABD-1
Genre: Journal Article

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 Creators:
Sparks, David S., Author
Saifzadeh, Siamak, Author
Savi, Flavia Medeiros, Author
Dlaska, Constantin E., Author
Berner, Arne, Author
Henkel, Jan, Author
Reichert, Johannes C., Author
Wullschleger, Martin, Author
Ren, Jiongyu, Author
Cipitria, Amaia1, Author              
McGovern, Jacqui A., Author
Steck, Roland, Author
Wagels, Michael, Author
Woodruff, Maria Ann, Author
Schuetz, Michael A., Author
Hutmacher, Dietmar W., Author
Affiliations:
1Amaia Cipitria, Biomaterialien, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_2489692              

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Free keywords: Implants; Musculoskeletal models; Preclinical research; Tissue engineering
 Abstract: Critical-size bone defects, which require large-volume tissue reconstruction, remain a clinical challenge. Bone engineering has the potential to provide new treatment concepts, yet clinical translation requires anatomically and physiologically relevant preclinical models. The ovine critical-size long-bone defect model has been validated in numerous studies as a preclinical tool for evaluating both conventional and novel bone-engineering concepts. With sufficient training and experience in large-animal studies, it is a technically feasible procedure with a high level of reproducibility when appropriate preoperative and postoperative management protocols are followed. The model can be established by following a procedure that includes the following stages: (i) preoperative planning and preparation, (ii) the surgical approach, (iii) postoperative management, and (iv) postmortem analysis. Using this model, full results for peer-reviewed publication can be attained within 2 years. In this protocol, we comprehensively describe how to establish proficiency using the preclinical model for the evaluation of a range of bone defect reconstruction options.

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Language(s): eng - English
 Dates: 2020-02-142020
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1038/s41596-019-0271-2
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Title: Nature Protocols
  Other : Nat. Protoc.
Source Genre: Journal
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Publ. Info: London, UK : Nature research
Pages: - Volume / Issue: 15 (3) Sequence Number: - Start / End Page: 877 - 924 Identifier: ISSN: 1750-2799