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  Switching between individual and collective motility in B lymphocytes is controlled by cell-matrix adhesion and inter-cellular interactions

Rey-Barroso, J., Calovi, D. S., Combe, M., German, Y., Moreau, M., Canivet, A., et al. (2018). Switching between individual and collective motility in B lymphocytes is controlled by cell-matrix adhesion and inter-cellular interactions. Scientific Reports, 8: 5800. doi:10.1038/s41598-018-24222-4.

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Rey-Barroso, J., Author
Calovi, Daniel S.1, Author              
Combe, M., Author
German, Y., Author
Moreau, M., Author
Canivet, A., Author
Wang, X. B., Author
Sire, C., Author
Theraulaz, G., Author
Dupre, L., Author
Affiliations:
1Centre de Recherches sur la Cognition Animale (CRCA), ou_persistent22              

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 Abstract: Lymphocytes alternate between phases of individual migration across tissues and phases of clustering during activation and function. The range of lymphocyte motility behaviors and the identity of the factors that govern them remain elusive. To explore this point, we here collected unprecedented statistics pertaining to cell displacements, cell: matrix and cell: cell interactions using a model B cell line as well as primary human B lymphocytes. At low cell density, individual B lymphocytes displayed a high heterogeneity in their speed and diffusivity. Beyond this intrinsic variability, B lymphocytes adapted their motility to the composition of extra-cellular matrix, adopting slow persistent walks over collagen IV and quick Brownian walks over fibronectin. At high cell density, collagen IV favored the self-assembly of B lymphocytes into clusters endowed with collective coordination, while fibronectin stimulated individual motility. We show that this behavioral plasticity is controlled by acto-myosin dependent adhesive and Arp2/3-dependent protrusive actin pools, respectively. Our study reveals the adaptive nature of B lymphocyte motility and group dynamics, which are shaped by an interplay between and cell: matrix and cell: cell interactions.

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 Dates: 2018-04-11
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: Other: WOS:000429684000009
DOI: 10.1038/s41598-018-24222-4
ISSN: 2045-2322
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Title: Scientific Reports
  Abbreviation : Sci. Rep.
Source Genre: Journal
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Publ. Info: London, UK : Nature Publishing Group
Pages: - Volume / Issue: 8 Sequence Number: 5800 Start / End Page: - Identifier: ISSN: 2045-2322
CoNE: https://pure.mpg.de/cone/journals/resource/2045-2322