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  Meiotic sex chromosome cohesion and autosomal synapsis are supported by Esco2.

McNicoll, F., Kühnel, A., Biswas, U., Hempel, K., Whelan, G., Eichele, G., et al. (2020). Meiotic sex chromosome cohesion and autosomal synapsis are supported by Esco2. Life Science Alliance, 3(3): e201900564. doi:10.26508/lsa.201900564.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0005-AC45-C Version Permalink: http://hdl.handle.net/21.11116/0000-0005-AC48-9
Genre: Journal Article

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McNicoll, F., Author
Kühnel, A., Author
Biswas, U., Author
Hempel, K., Author
Whelan, G.1, Author              
Eichele, G.1, Author              
Jessberger, R., Author
Affiliations:
1Department of Genes and Behavior, MPI for biophysical chemistry, Max Planck Society, ou_persistent34              

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 Abstract: In mitotic cells, establishment of sister chromatid cohesion requires acetylation of the cohesin subunit SMC3 (acSMC3) by ESCO1 and/or ESCO2. Meiotic cohesin plays additional but poorly understood roles in the formation of chromosome axial elements (AEs) and synaptonemal complexes. Here, we show that levels of ESCO2, acSMC3, and the pro-cohesion factor sororin increase on meiotic chromosomes as homologs synapse. These proteins are less abundant on the largely unsynapsed sex chromosomes, whose sister chromatid cohesion appears weaker throughout the meiotic prophase. Using three distinct conditional Esco2 knockout mouse strains, we demonstrate that ESCO2 is essential for male gametogenesis. Partial depletion of ESCO2 in prophase I spermatocytes delays chromosome synapsis and further weakens cohesion along sex chromosomes, which show extensive separation of AEs into single chromatids. Unsynapsed regions of autosomes are associated with the sex chromatin and also display split AEs. This study provides the first evidence for a specific role of ESCO2 in mammalian meiosis, identifies a particular ESCO2 dependence of sex chromosome cohesion and suggests support of autosomal synapsis by acSMC3-stabilized cohesion.

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Language(s): eng - English
 Dates: 2020-02-122020-03
 Publication Status: Published in print
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.26508/lsa.201900564
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Title: Life Science Alliance
Source Genre: Journal
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Pages: 17 Volume / Issue: 3 (3) Sequence Number: e201900564 Start / End Page: - Identifier: -