English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  The maintenance and regeneration of the planarian excretory system are regulated by EGFR signaling.

Rink, J. C., Vu, H. T. K., & Alvarado, A. S. (2011). The maintenance and regeneration of the planarian excretory system are regulated by EGFR signaling. Development, 138(17), 3769-3780. doi:10.1242/dev.066852.

Item is

Basic

show hide
Genre: Journal Article

Files

show Files
hide Files
:
3194038.pdf (Publisher version), 4MB
 
File Permalink:
-
Name:
3194038.pdf
Description:
-
Visibility:
Restricted ( Max Planck Society (every institute); )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Rink, J. C.1, Author              
Vu, H. T. K.1, Author              
Alvarado, A. S., Author
Affiliations:
1Department of Tissue Dynamics and Regeneration, MPI for Biophysical Chemistry, Max Planck Society, ou_3181978              

Content

show
hide
Free keywords: Planaria; Protonephridia; Branching morphogenesis
 Abstract: The maintenance of organs and their regeneration in case of injury are crucial to the survival of all animals. High rates of tissue turnover and nearly unlimited regenerative capabilities make planarian flatworms an ideal system with which to investigate these important processes, yet little is known about the cell biology and anatomy of their organs. Here we focus on the planarian excretory system, which consists of internal protonephridial tubules. We find that these assemble into complex branching patterns with a stereotyped succession of cell types along their length. Organ regeneration is likely to originate from a precursor structure arising in the blastema, which undergoes extensive branching morphogenesis. In an RNAi screen of signaling molecules, we identified an EGF receptor (Smed-EGFR-5) as a crucial regulator of branching morphogenesis and maintenance. Overall, our characterization of the planarian protonephridial system establishes a new paradigm for regenerative organogenesis and provides a platform for exploring its functional and evolutionary homologies with vertebrate excretory systems.

Details

show
hide
Language(s): eng - English
 Dates: 2011
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1242/dev.066852
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Development
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 138 (17) Sequence Number: - Start / End Page: 3769 - 3780 Identifier: -