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  Therapy of treatment resistant depression: Focus on the management of TRD with atypical antipsychotics

Klein, N., Sacher, J., Wallner, H., Tauscher, J., & Kasper, S. (2004). Therapy of treatment resistant depression: Focus on the management of TRD with atypical antipsychotics. CNS Spectrums, 9(11), 823-832. doi:10.1017/S1092852900002248.

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Genre: Journal Article

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 Creators:
Klein , Nikolas1, Author
Sacher, Julia1, Author              
Wallner, Helene1, Author
Tauscher, Johannes1, Author
Kasper, Siegfried1, Author
Affiliations:
1External Organizations, ou_persistent22              

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Free keywords: placebo-controlled trial; serotonin reuptake inhibitors; treatment-refractory depression; transcranial magnetic stimulation; major depression; lithium augmentation; antidepressant treatment; combination treatment; electroconvulsive-therapy
 Abstract: Treatment-resistant depression (TRD) represents a significant challenge for physicians. About one third of patients with major depressive disorder fail to experience sufficient symptom improvement despite adequate treatment. Despite this high occurrence of TRD there was no general consensus on diagnosis criteria for TRD until 1997 when researchers proposed a model of defining and staging TRD. In 1999, others defined operational criteria for the definition of TRD. Treatment of TRD is commonly separated into pharmacologic and nonpharmacologic methods. This review gives a short overview of these two methods. The nonpharmacologic methods include psychotherapy, electroconvulsive therapy, and vagus nerve stimulation. Pharmacologic methods include switching to another antidepressant monotherapy, and augmentation or combination with two or more antidepressants or other agents. This review especially focuses on the augmentation of the antidepressant therapy with atypical antipsychotics.

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Language(s): eng - English
 Dates: 2014-11-072004-11
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1017/S1092852900002248
PMID: 15520606
 Degree: -

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Title: CNS Spectrums
  Other : CNS Spectr.
Source Genre: Journal
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Publ. Info: New York, NY : MBL Communications
Pages: - Volume / Issue: 9 (11) Sequence Number: - Start / End Page: 823 - 832 Identifier: ISSN: 1092-8529
CoNE: https://pure.mpg.de/cone/journals/resource/991042752686328