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  Atypical functional connectome hierarchy in autism

Hong, S.-J., De Wael, R. V., Bethlehem, R. A. I., Lariviere, S., Paquola, C., Valk, S. L., et al. (2019). Atypical functional connectome hierarchy in autism. Nature Communications, 10(1), 1-13. doi:10.1038/s41467-019-08944-1.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0005-AD98-D Version Permalink: http://hdl.handle.net/21.11116/0000-0005-AD99-C
Genre: Journal Article

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 Creators:
Hong , Seok-Jun1, Author
De Wael, Reinder Vos1, Author
Bethlehem, Richard A. I.1, Author
Lariviere, Sara1, Author
Paquola, Casey1, Author
Valk, Sofie L.1, Author              
Milham, Michael P.1, Author
Di Martino, Adriana1, Author
Margulies, Daniel S.1, Author              
Smallwood, Jonathan1, Author              
Bernhardt, Boris C.1, Author              
Affiliations:
1External Organizations, ou_persistent22              

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Free keywords: Adolescent; Adult; Autistic disorder; Autism spectrum disorder; Cerebral cortex; Cortical hierarchy; Connectome gradient; Resting state functional connectivity; Magnetic resonance imaging; Social behaviour disorders; Physiopathology
 Abstract: One paradox of autism is the co-occurrence of deficits in sensory and higher-order socio-cognitive processing. Here, we examined whether these phenotypical patterns may relate to an overarching system-level imbalance—specifically a disruption in macroscale hierarchy affecting integration and segregation of unimodal and transmodal networks. Combining connectome gradient and stepwise connectivity analysis based on task-free functional magnetic resonance imaging (fMRI), we demonstrated atypical connectivity transitions between sensory and higher-order default mode regions in a large cohort of individuals with autism relative to typically-developing controls. Further analyses indicated that reduced differentiation related to perturbed stepwise connectivity from sensory towards transmodal areas, as well as atypical long-range rich-club connectivity. Supervised pattern learning revealed that hierarchical features predicted deficits in social cognition and low-level behavioral symptoms, but not communication-related symptoms. Our findings provide new evidence for imbalances in network hierarchy in autism, which offers a parsimonious reference frame to consolidate its diverse features.

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Language(s): eng - English
 Dates: 2018-04-132019-02-062019-03-04
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1038/s41467-019-08944-1
PMID: 30833582
PMC: PMC6399265
 Degree: -

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Title: Nature Communications
  Abbreviation : Nat. Commun.
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 10 (1) Sequence Number: - Start / End Page: 1 - 13 Identifier: ISSN: 2041-1723
CoNE: https://pure.mpg.de/cone/journals/resource/2041-1723