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  Atypical functional connectome hierarchy in autism

Hong, S.-J., De Wael, R. V., Bethlehem, R. A. I., Lariviere, S., Paquola, C., Valk, S. L., et al. (2019). Atypical functional connectome hierarchy in autism. Nature Communications, 10(1), 1-13. doi:10.1038/s41467-019-08944-1.

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Hong , Seok-Jun1, Autor
De Wael, Reinder Vos1, Autor
Bethlehem, Richard A. I.1, Autor
Lariviere, Sara1, Autor
Paquola, Casey1, Autor
Valk, Sofie L.1, Autor           
Milham, Michael P.1, Autor
Di Martino, Adriana1, Autor
Margulies, Daniel S.1, Autor           
Smallwood, Jonathan1, Autor           
Bernhardt, Boris C.1, Autor           
Affiliations:
1External Organizations, ou_persistent22              

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Schlagwörter: Adolescent; Adult; Autistic disorder; Autism spectrum disorder; Cerebral cortex; Cortical hierarchy; Connectome gradient; Resting state functional connectivity; Magnetic resonance imaging; Social behaviour disorders; Physiopathology
 Zusammenfassung: One paradox of autism is the co-occurrence of deficits in sensory and higher-order socio-cognitive processing. Here, we examined whether these phenotypical patterns may relate to an overarching system-level imbalance—specifically a disruption in macroscale hierarchy affecting integration and segregation of unimodal and transmodal networks. Combining connectome gradient and stepwise connectivity analysis based on task-free functional magnetic resonance imaging (fMRI), we demonstrated atypical connectivity transitions between sensory and higher-order default mode regions in a large cohort of individuals with autism relative to typically-developing controls. Further analyses indicated that reduced differentiation related to perturbed stepwise connectivity from sensory towards transmodal areas, as well as atypical long-range rich-club connectivity. Supervised pattern learning revealed that hierarchical features predicted deficits in social cognition and low-level behavioral symptoms, but not communication-related symptoms. Our findings provide new evidence for imbalances in network hierarchy in autism, which offers a parsimonious reference frame to consolidate its diverse features.

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Sprache(n): eng - English
 Datum: 2018-04-132019-02-062019-03-04
 Publikationsstatus: Online veröffentlicht
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: DOI: 10.1038/s41467-019-08944-1
PMID: 30833582
PMC: PMC6399265
 Art des Abschluß: -

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Titel: Nature Communications
  Kurztitel : Nat. Commun.
Genre der Quelle: Zeitschrift
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Affiliations:
Ort, Verlag, Ausgabe: London : Nature Publishing Group
Seiten: - Band / Heft: 10 (1) Artikelnummer: - Start- / Endseite: 1 - 13 Identifikator: ISSN: 2041-1723
CoNE: https://pure.mpg.de/cone/journals/resource/2041-1723