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  Effects of soy lecithin phosphatidic acid and phosphatidylserine complex (PAS) on the endocrine and psychological responses to mental stress

Hellhammer, J., Fries, E., Buss, C., Engert, V., Tuch, A., Rutenberg, D., et al. (2004). Effects of soy lecithin phosphatidic acid and phosphatidylserine complex (PAS) on the endocrine and psychological responses to mental stress. Stress-the International Journal on the Biology of Stress, 7(2), 119-126. doi:10.1080/10253890410001728379.

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 Creators:
Hellhammer, J.1, Author
Fries, E.1, Author
Buss, C. 1, Author
Engert, Veronika1, Author           
Tuch, A.1, Author
Rutenberg, D.1, Author
Hellhammer, D.1, Author
Affiliations:
1External Organizations, ou_persistent22              

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Free keywords: ACTH; Cortisol; Phosphatidic acid; Phosphatidylserine, STAI, Stress
 Abstract: Phosphatidylserine, derived from cow brains, has been shown previously to dampen the ACTH and cortisol response to physical stress. Further research investigated the influence of soy lecithin phosphatidylserine supplementation on mood and heart rate when faced with an acute stressor. In this study, we investigated the effects of soy lecithin phosphatidic acid and phosphatidylserine complex (PAS) supplementation on pituitary adrenal reactivity (ACTH, cortisol) and on the psychological response (Spielberger State Anxiety Inventory stress subscale) to a mental and emotional stressor. Four groups of 20 subjects were treated for three weeks with daily dosages of either 400 mg PAS, 600 mg PAS, 800 mg PAS, or placebo before exposure to the Trier Social Stress Test (TSST). Treatment with 400 mg PAS resulted in a pronounced blunting of both serum ACTH and cortisol, and salivary cortisol responses to the TSST, but did not affect heart rate. The effect was not seen with larger doses of PAS. With regard to the psychological response, 400 mg PAS seemed to exert a specific positive effect on emotional responses to the TSST. While the placebo group showed the expected increase in distress after the test, the group treated with 400 mg PAS showed decreased distress. These data provide initial evidence for a selective stress dampening effect of PAS on the pituitary–adrenal axis, suggesting the potential of PAS in the treatment of stress related disorders.

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Language(s): eng - English
 Dates: 2004-05-172004-02-072004-05-282009-07-072004-06
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1080/10253890410001728379
PMID: 15512856
 Degree: -

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Title: Stress-the International Journal on the Biology of Stress
  Other : Stress
Source Genre: Journal
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Publ. Info: London : Gordon and Breach
Pages: - Volume / Issue: 7 (2) Sequence Number: - Start / End Page: 119 - 126 Identifier: ISSN: 1025-3890
CoNE: https://pure.mpg.de/cone/journals/resource/954927713316