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  Enhanced glucocorticoid sensitivity in patients with chronic fatigue syndrome

Gaab, J., Rohleder, N., Heitz, V., Schad, T., Engert, V., Schürmeyer, T. H., et al. (2003). Enhanced glucocorticoid sensitivity in patients with chronic fatigue syndrome. Acta Neuropsychiatrica, 15(4), 184-191. doi:10.1034/j.1601-5215.2003.00033.x.

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Genre: Journal Article

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 Creators:
Gaab, Jens1, Author
Rohleder, Nicolas1, Author
Heitz, Vera1, Author
Schad, Tanja1, Author
Engert, Veronika1, Author              
Schürmeyer, Thomas H.1, Author
Ehlert, Ulrike1, Author
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1External Organizations, ou_persistent22              

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Free keywords: ACTH; Chronic fatigue syndrome; Cortisol; Dexamethasone; Glucocorticoid sensitivity; HPA axis; Interleukin-6; Psychosocial stress; Tumor necrosis factor-alpha
 Abstract: Objective: Alterations of the immune-neuroendocrine interplay have been described in chronic fatigue syndrome (CFS). Employing a recently developed method, the study set out to investigate whether patients with CFS have an altered sensitivity to glucocorticoids (GCs) when under stress.; Methods: A total of 21 CFS patients and 20 healthy age- and gender-matched controls underwent a standardized psychosocial stress test (Trier Social Stress Test, TSST). Salivary and plasma cortisol levels were measured repeatedly following exposure to the stressor. GC sensitivity was assessed in vitro by dexamethasone inhibition of lipopolysaccharide-stimulated production of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNC-α).; Results: Cortisol responses following the TSST did not differ significantly between CFS patients and healthy controls. GC sensitivity differed significantly between CFS patients and healthy controls, with CFS patients showing a greater sensitivity towards GCs (TNF-α: F 1/39 = 7.32, P = 0.01; IL-6: F 1/39 = 9.73, P = 0.004).; Conclusion: Consistent with recent evidence, CFS patients are characterized by an enhanced sensitivity to glucocorticoids. The implications for secondary processes, such as the regulatory influence of glucocorticoids on immune processes, are discussed.

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Language(s): eng - English
 Dates: 2003-07-282003-08
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1034/j.1601-5215.2003.00033.x
PMID: 26983566
 Degree: -

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Title: Acta Neuropsychiatrica
Source Genre: Journal
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Publ. Info: Cambridge : Cambridge University Press
Pages: - Volume / Issue: 15 (4) Sequence Number: - Start / End Page: 184 - 191 Identifier: ISSN: 1601-5215
CoNE: https://pure.mpg.de/cone/journals/resource/1601-5215