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  Assessment of cortisol response with low-dose and high-dose ACTH in patients with chronic fatigue syndrome and healthy comparison subjects

Gaab, J., Hüster, D., Peisen, R., Engert, V., Heitz, V., Schad, T., et al. (2003). Assessment of cortisol response with low-dose and high-dose ACTH in patients with chronic fatigue syndrome and healthy comparison subjects. Psychosomatics, 44(2), 113-119. doi:10.1176/appi.psy.44.2.113.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0005-B1D9-E Version Permalink: http://hdl.handle.net/21.11116/0000-0005-B1DA-D
Genre: Journal Article

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 Creators:
Gaab, Jens1, Author
Hüster, D.1, Author
Peisen, R.1, Author
Engert, Veronika1, Author              
Heitz, V.1, Author
Schad, T.1, Author
Schürmeyer, Th.1, Author
Ehlert, U.1, Author
Affiliations:
1External Organizations, ou_persistent22              

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Free keywords: Chronic fatigue syndrome
 Abstract: A reduced secretion of cortisol has been proposed as a possible explanation of the symptoms in chronic fatigue syndrome. However, the evidence of hypocortisolism in chronic fatigue syndrome is conflicting. In order to simultaneously assess possible alterations in adrenocortical sensitivity and secretory adrenal reserve, the authors administered both low-dose and high-dose ACTH to a group of 18 chronic fatigue syndrome patients and 18 age- and gender-matched healthy comparison subjects. No response differences for salivary and plasma cortisol were detectable after administration of either low-dose or high-dose ACTH, indicating that primary adrenal insufficiency is unlikely to play a significant role in the etiology of chronic fatigue syndrome.

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Language(s): eng - English
 Dates: 2002-07-272002-03-062002-08-012011-04-192003-03
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1176/appi.psy.44.2.113
PMID: 12618533
 Degree: -

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Title: Psychosomatics
Source Genre: Journal
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Publ. Info: New York : Elsevier
Pages: - Volume / Issue: 44 (2) Sequence Number: - Start / End Page: 113 - 119 Identifier: ISSN: 0033-3182
CoNE: https://pure.mpg.de/cone/journals/resource/0033-3182