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  Low-dose dexamethasone suppression test in chronic fatigue syndrome and health

Gaab, J., Hüster, D., Peisen, R., Engert, V., Schad, T., Schürmeyer, T. H., et al. (2002). Low-dose dexamethasone suppression test in chronic fatigue syndrome and health. Psychosomatic Medicine, 64(2), 311-318. doi:10.1097/00006842-200203000-00015.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0005-B1DE-9 Version Permalink: http://hdl.handle.net/21.11116/0000-0005-B1DF-8
Genre: Journal Article

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 Creators:
Gaab, Jens1, Author
Hüster, Dominik1, Author
Peisen, Renate1, Author
Engert, Veronika1, Author              
Schad, Tanja1, Author
Schürmeyer, Thomas H.1, Author
Ehlert, Ulrike1, Author
Affiliations:
1External Organizations, ou_persistent22              

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Free keywords: Chronic fatigue syndrome; HPA axis; Salivary cortisol; Dexamethasone
 Abstract: Objective: Subtle dysregulations of the hypothalamus-pituitary-adrenal axis in chronic fatigue syndrome have been described. The aim of this study was to examine the negative feedback regulations of the hypothalamus-pituitary-adrenal axis in chronic fatigue syndrome.; Methods: In 21 patients with chronic fatigue syndrome and 21 healthy control subjects, awakening and circadian salivary free cortisol profiles were assessed over 2 consecutive days and compared with awakening and circadian salivary free cortisol profiles after administration of 0.5 mg of dexamethasone at 11:00 PM the previous day.; Results: Patients with chronic fatigue syndrome had normal salivary free cortisol profiles but showed enhanced and prolonged suppression of salivary free cortisol after the administration of 0.5 mg of dexamethasone in comparison to the control subjects.; Conclusions: Enhanced negative feedback of the hypothalamus-pituitary-adrenal axis could be a plausible explanation for the previously described alterations in hypothalamus-pituitary-adrenal axis functioning in chronic fatigue syndrome. Because similar changes have been described in stress-related disorders, a putative role of stress in the pathogenesis of the enhanced feedback is possible.

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Language(s): eng - English
 Dates: 2001-05-212001-01-162002-03
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1097/00006842-200203000-00015
PMID: 11914448
 Degree: -

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Title: Psychosomatic Medicine
Source Genre: Journal
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Publ. Info: Baltimore, MD : Lippincott Williams & Wilkins
Pages: - Volume / Issue: 64 (2) Sequence Number: - Start / End Page: 311 - 318 Identifier: ISSN: 0033-3174
CoNE: https://pure.mpg.de/cone/journals/resource/954925436479