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  From TOM to the TIM23 complex - handing over of a precursor.

Callegari, S., Cruz-Zaragoza, L. D., & Rehling, P. (2020). From TOM to the TIM23 complex - handing over of a precursor. Biological Chemistry, (in press). doi:10.1515/hsz-2020-0101.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0005-B6A8-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0005-B6AA-E
Genre: Journal Article

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 Creators:
Callegari, S., Author
Cruz-Zaragoza, L. D., Author
Rehling, P.1, Author              
Affiliations:
1Max Planck Fellow Peter Rehling, ou_1298545              

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Free keywords: TIM23 complex; TIM50; membrane translocation; mitochondria; presequence pathway; protein translocation
 Abstract: Mitochondrial precursor proteins with amino-terminal presequences are imported via the presequence pathway, utilizing the TIM23 complex for inner membrane translocation. Initially, the precursors pass the outer membrane through the TOM complex and are handed over to the TIM23 complex where they are sorted into the inner membrane or translocated into the matrix. This handover process depends on the receptor proteins at the inner membrane, Tim50 and Tim23, which are critical for efficient import. In this review, we summarize key findings that shaped the current concepts of protein translocation along the presequence import pathway, with a particular focus on the precursor handover process from TOM to the TIM23 complex. In addition, we discuss functions of the human TIM23 pathway and the recently uncovered pathogenic mutations in TIM50.

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Language(s): eng - English
 Dates: 2020-02-01
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1515/hsz-2020-0101
 Degree: -

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Title: Biological Chemistry
Source Genre: Journal
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Pages: - Volume / Issue: - Sequence Number: (in press) Start / End Page: - Identifier: -