English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  A circuit topology approach to categorizing changes in biomolecular structure

Schullian, O., Woodard, J., Tirandaz, A., & Mashaghi, A. (2020). A circuit topology approach to categorizing changes in biomolecular structure. Frontiers in Physics, 8: 5. doi:10.3389/fphy.2020.00005.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0005-B90B-F Version Permalink: http://hdl.handle.net/21.11116/0000-0005-B90C-E
Genre: Journal Article

Files

show Files
hide Files
:
Article.pdf (Publisher version), 2MB
Name:
Article.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-

Locators

show

Creators

show
hide
 Creators:
Schullian, Otto1, Author              
Woodard, Jaie, Author
Tirandaz, Arash, Author
Mashaghi, Alireza, Author
Affiliations:
1Markus Miettinen, Theorie & Bio-Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_3070372              

Content

show
hide
Free keywords: -
 Abstract: The biological world is composed of folded linear molecules of bewildering topological complexity and diversity. The topology of folded biomolecules such as proteins and ribonucleic acids is often subject to change during biological processes. Despite intense research, we lack a solid mathematical framework that summarizes these operations in a principled manner. Circuit topology, which formalizes the arrangements of intramolecular contacts, serves as a general mathematical framework to analyze the topological characteristics of folded linear molecules. In this work, we translate familiar molecular operations in biology, such as duplication, permutation, and elimination of contacts, into the language of circuit topology. We show that for such operations there are corresponding matrix representations as well as basic rules that serve as a foundation for understanding these operations within the context of a coherent algebraic framework. We present several biological examples and provide a simple computational framework for creating and analyzing the circuit diagrams of proteins and nucleic acids. We expect our study and future developments in this direction to facilitate a deeper understanding of natural molecular processes and to provide guidance to engineers for generating complex polymeric materials.

Details

show
hide
Language(s): eng - English
 Dates: 2020-01-302020
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.3389/fphy.2020.00005
BibTex Citekey: 10.3389/fphy.2020.00005
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Frontiers in Physics
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Lausanne : Frontiers Media
Pages: - Volume / Issue: 8 Sequence Number: 5 Start / End Page: - Identifier: ISSN: 2296-424X