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  Dynamic actuation of DNA-assembled plasmonic nanostructures in microfluidic cell-sized compartments

Göpfrich, K., Urban, M. J., Frey, C., Platzman, I., Spatz, J. P., & Liu, N. (2020). Dynamic actuation of DNA-assembled plasmonic nanostructures in microfluidic cell-sized compartments. Nano Letters, 20(3), 1571-1577. doi:10.1021/acs.nanolett.9b04217.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0005-BB43-D Version Permalink: http://hdl.handle.net/21.11116/0000-0006-099B-2
Genre: Journal Article

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 Creators:
Göpfrich, Kerstin1, Author              
Urban, Maximilian J, Author
Frey, Christoph1, 2, Author              
Platzman, Ilia1, 2, Author              
Spatz, Joachim P.1, 2, Author              
Liu, Na, Author
Affiliations:
1Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              
2Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany, ou_persistent22              

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Free keywords: DNA origami ; plasmonic nanostructures ; droplet-based microfluidics ; pH switch ; plasmonic enantiomer selection
 Abstract: Molecular motor proteins form the basis of cellular dynamics. Recently, notable efforts have led to the creation of their DNA-based mimics, which can carry out complex nanoscale motion. However, such functional analogues have not yet been integrated or operated inside synthetic cells towards the goal of realizing artificial biological systems entirely from the bottom-up. In this Letter, we encapsulate and actuate DNA-assembled dynamic nanostructures inside cell-sized microfluidic compartments. These encapsulated DNA nanostructures not only exhibit structural reconfigurability owing to their pH-sensitive molecular switches upon external stimuli, but also possess optical feedback enabled by the integrated plasmonic probes. In particular, we demonstrate the power of microfluidic compartmentalization for achieving on-chip plasmonic enantiomer separation and substrate filtration. Our work exemplifies that the two unique tools, microfluidics and DNA technology, offering high precision on the microscale and nanoscale, respectively, can be brought together to greatly enrich the complexity and diversity of functional synthetic systems.

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Language(s): eng - English
 Dates: 2020-02-202019-10-122020-02-212020
 Publication Status: Published in print
 Pages: 24
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1021/acs.nanolett.9b04217
 Degree: -

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Title: Nano Letters
  Abbreviation : Nano Lett.
Source Genre: Journal
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Publ. Info: Washington, DC : American Chemical Society
Pages: - Volume / Issue: 20 (3) Sequence Number: - Start / End Page: 1571 - 1577 Identifier: ISSN: 1530-6984
CoNE: https://pure.mpg.de/cone/journals/resource/110978984570403