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  Bariatric surgery and brain health: A longitudinal observational study investigating the effect of surgery on cognitive function and gray matter volume

Prehn, K., Profitlich, T., Rangus, I., Heßler, S., Witte, A. V., Grittner, U., et al. (2020). Bariatric surgery and brain health: A longitudinal observational study investigating the effect of surgery on cognitive function and gray matter volume. Nutrients, 12(1): 127. doi:10.3390/nu12010127.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0005-BD32-E Version Permalink: http://hdl.handle.net/21.11116/0000-0005-BD5A-2
Genre: Journal Article

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 Creators:
Prehn, Kristin1, Author              
Profitlich, Thorge1, Author
Rangus, Ida1, Author
Heßler, Sebastian1, Author
Witte, A. Veronica1, 2, Author              
Grittner, Ulrike1, Author
Ordemann, Jürgen1, Author
Flöel, Agnes1, Author
Affiliations:
1External Organizations, ou_persistent22              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              

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Free keywords: Roux-en-Y; Gastric bypass; Executive functions; Voxel-based morphometry; Fronto-temporal cortex; Nucleus acumbens
 Abstract: Dietary modifications leading to weight loss have been suggested as a means to improve brain health. In morbid obesity, bariatric surgery (BARS)—including different procedures, such as vertical sleeve gastrectomy (VSG), gastric banding (GB), or Roux-en-Y gastric bypass (RYGB) surgery—is performed to induce rapid weight loss. Combining reduced food intake and malabsorption of nutrients, RYGB might be most effective, but requires life-long follow-up treatment. Here, we tested 40 patients before and six months after surgery (BARS group) using a neuropsychological test battery and compared them with a waiting list control group. Subsamples of both groups underwent structural MRI and were examined for differences between surgical procedures. No substantial differences between BARS and control group emerged with regard to cognition. However, larger gray matter volume in fronto-temporal brain areas accompanied by smaller volume in the ventral striatum was seen in the BARS group compared to controls. RYGB patients compared to patients with restrictive treatment alone (VSG/GB) had higher weight loss, but did not benefit more in cognitive outcomes. In sum, the data of our study suggest that BARS might lead to brain structure reorganization at long-term follow-up, while the type of surgical procedure does not differentially modulate cognitive performance.

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Language(s): eng - English
 Dates: 2019-12-132019-11-152019-12-282020-01-02
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.3390/nu12010127
PMID: 31906475
PII: E127
 Degree: -

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Project name : NeuroCure - neue Perspektiven in der Therapie neurologischer Erkrankungen / EXC 257
Grant ID : Fl 379-16/1
Funding program : -
Funding organization : Deutsche Forschungsgemeinschaft (DFG)
Project name : -
Grant ID : 01GQ1420B
Funding program : -
Funding organization : German Federal Ministry of Education and Research (BMBF)
Project name : -
Grant ID : 393148499
Funding program : -
Funding organization : DFG (German Research Foundation)
Project name : -
Grant ID : -
Funding program : Open Access Publication Fund
Funding organization : University of Greifswald

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Title: Nutrients
Source Genre: Journal
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Publ. Info: Basel : MDPI
Pages: - Volume / Issue: 12 (1) Sequence Number: 127 Start / End Page: - Identifier: ISSN: 2072-6643
CoNE: https://pure.mpg.de/cone/journals/resource/2072-6643