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  Light microscopy of mitochondria at the nanoscale.

Jakobs, S., Stephan, T., Ilgen, P., & Brueser, C. (2020). Light microscopy of mitochondria at the nanoscale. Annual Review of Biophysics, 49: (in press). doi:10.1146/annurev-biophys-121219-081550.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0005-BE32-D Version Permalink: http://hdl.handle.net/21.11116/0000-0005-DBB9-4
Genre: Journal Article

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 Creators:
Jakobs, S.1, Author              
Stephan, T.2, Author              
Ilgen, P.3, Author              
Brueser, C.2, Author              
Affiliations:
1Research Group of High Resolution Optical Microscopy, MPI for Biophysical Chemistry, Max Planck Society, ou_578626              
2Research Group of Mitochondrial Structure and Dynamics, MPI for Biophysical Chemistry, Max Planck Society, ou_578566              
3Department of NanoBiophotonics, MPI for Biophysical Chemistry, Max Planck Society, ou_578627              

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 Abstract: Mitochondria are essential for eukaryotic life. These double-membrane organelles often form highly dynamic tubular networks interacting with many cellular structures. Their highly convoluted contiguous inner membrane compartmentalizes the organelle, which is crucial for mitochondrial function. Since the diameter of the mitochondrial tubules is generally close to the diffraction limit of light microcopy, it is often challenging, if not impossible, to visualize submitochondrial structures or protein distributions using conventional light microscopy. This renders super-resolution microscopy particularly valuable, and attractive, for studying mitochondria. Super-resolution microscopy encompasses a diverse set of approaches that extend resolution, as well as nanoscopy techniques that can even overcome the diffraction limit. In this review, we provide an overview of recent studies using super-resolution microscopy to investigate mitochondria, discuss the strengths and opportunities of the various methods in addressing specific questions in mitochondrial biology, and highlight potential future developments. Expected final online publication date for the Annual Review of Biophysics, Volume 49 is May 6, 2020. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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Language(s): eng - English
 Dates: 2020-02-24
 Publication Status: Published online
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 Rev. Method: Peer
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Title: Annual Review of Biophysics
Source Genre: Journal
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Pages: - Volume / Issue: 49 Sequence Number: (in press) Start / End Page: - Identifier: -