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  Genomic donor cassette sharing during VLRA and VLRC assembly in jawless vertebrates

Das, S., Li, J., Holland, S. J., Iyer, L. M., Hirano, M., Schorrp, M., et al. (2014). Genomic donor cassette sharing during VLRA and VLRC assembly in jawless vertebrates. Proceedings of the National Academy of Sciences of the United States of America, 111, 14828-14833. doi:10.1073/pnas.1415580111.

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Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-0005-BF63-5 Versions-Permalink: https://hdl.handle.net/21.11116/0000-0009-1FA6-A
Genre: Zeitschriftenartikel

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Das et al..pdf (Verlagsversion), 912KB
 
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 Urheber:
Das, Sabyasachi1, Autor
Li, Jianxu1, Autor
Holland, Stephen J.2, Autor
Iyer, Lakshminarayan M.1, Autor
Hirano, Masayuki1, Autor
Schorrp, Michael2, Autor
Aravind, L.1, Autor
Cooper, Max D.1, Autor
Boehm, Thomas2, Autor           
Affiliations:
1External Organizations, ou_persistent22              
2Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243647              

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 Zusammenfassung: Lampreys possess two T-like lymphocyte lineages that express either variable lymphocyte receptor (VLR) A or VLRC antigen receptors. VLRA+ and VLRC+ lymphocytes share many similarities with the two principal T-cell lineages of jawed vertebrates expressing the αβ and γδ T-cell receptors (TCRs). During the assembly of VLR genes, several types of genomic cassettes are inserted, in step-wise fashion, into incomplete germ-line genes to generate the mature forms of antigen receptor genes. Unexpectedly, the structurally variable components of VLRA and VLRC receptors often possess partially identical sequences; this phenomenon of module sharing between these two VLR isotypes occurs in both lampreys and hagfishes. By contrast, VLRA and VLRC molecules typically do not share their building blocks with the structurally analogous VLRB receptors that are expressed by B-like lymphocytes. Our studies reveal that VLRA and VLRC germ-line genes are situated in close proximity to each other in the lamprey genome and indicate the interspersed arrangement of isotype-specific and shared genomic donor cassettes; these features may facilitate the shared cassette use. The genomic structure of the VLRA/VLRC locus in lampreys is reminiscent of the interspersed nature of the TCRA/TCRD locus in jawed vertebrates that also allows the sharing of some variable gene segments during the recombinatorial assembly of TCR genes.

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Sprache(n): eng - English
 Datum: 2014-10-14
 Publikationsstatus: Online veröffentlicht
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 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1073/pnas.1415580111
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Titel: Proceedings of the National Academy of Sciences of the United States of America
  Andere : Proc. Acad. Sci. USA
  Andere : Proc. Acad. Sci. U.S.A.
  Andere : Proceedings of the National Academy of Sciences of the USA
  Kurztitel : PNAS
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: Washington, D.C. : National Academy of Sciences
Seiten: - Band / Heft: 111 Artikelnummer: - Start- / Endseite: 14828 - 14833 Identifikator: ISSN: 0027-8424
CoNE: https://pure.mpg.de/cone/journals/resource/954925427230