English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
 
 
DownloadE-Mail
  The size of the immune repertoire of bacteria

Bradde, S., Nourmohammad, A., Goyal, S., & Balasubramanian, V. (2020). The size of the immune repertoire of bacteria. Proceedings of the National Academy of Sciences of the United States of America, 117(10), 5144-5151. doi:10.1073/pnas.1903666117.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0005-BF5C-E Version Permalink: http://hdl.handle.net/21.11116/0000-0005-DBC5-6
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Bradde, S., Author
Nourmohammad, Armita1, Author              
Goyal, S., Author
Balasubramanian, V., Author
Affiliations:
1Max Planck Research Group Statistical physics of evolving systems, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society, ou_2516692              

Content

show
hide
Free keywords: CRISPR-Cas; adaptive immunity; bacteria; optimal memory; phage
 Abstract: Some bacteria and archaea possess an immune system, based on the CRISPR-Cas mechanism, that confers adaptive immunity against viruses. In such species, individual prokaryotes maintain cassettes of viral DNA elements called spacers as a memory of past infections. Typically, the cassettes contain several dozen expressed spacers. Given that bacteria can have very large genomes and since having more spacers should confer a better memory, it is puzzling that so little genetic space would be devoted by prokaryotes to their adaptive immune systems. Here, assuming that CRISPR functions as a long-term memory-based defense against a diverse landscape of viral species, we identify a fundamental tradeoff between the amount of immune memory and effectiveness of response to a given threat. This tradeoff implies an optimal size for the prokaryotic immune repertoire in the observational range.

Details

show
hide
Language(s): eng - English
 Dates: 2020-02-182020-03-10
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1073/pnas.1903666117
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Proceedings of the National Academy of Sciences of the United States of America
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 117 (10) Sequence Number: - Start / End Page: 5144 - 5151 Identifier: -